dc.contributor.author | Walker, V. | |
dc.contributor.author | Stansbridge, E. M. | |
dc.contributor.author | Griffin, D. G. | |
dc.date.accessioned | 2018-09-20T16:27:55Z | |
dc.date.available | 2018-09-20T16:27:55Z | |
dc.date.issued | 2013-02-21 | |
dc.identifier.citation | Walker, V. Stansbridge, E. M.; Griffin, D. G. (2013). Demography and biochemistry of 2800 patients from a renal stones clinic. Annals of Clinical Biochemistry 50 (2), 127-139 | |
dc.identifier.issn | 0004-5632,1758-1001 | |
dc.identifier.uri | http://hdl.handle.net/10379/14334 | |
dc.description.abstract | Background: Because the causes of stones are uncertain, interventions to prevent recurrence have an insecure foundation. Progress depends on careful evaluation of stone formers.
Methods: A descriptive retrospective database study of 1983 men and 816 women from the Southampton stones clinic from 1990 to March 2007. Anonymized data from the first attendance were analysed using non-parametric statistical tests.
Results: Sex ratio (2.43:1), age (median 49 y, 2.5th-97.5th percentiles, 23-77 y men, 20-79 y women), recurrent stone formers (30%) and type of stone were similar to other centres. Women more often had a positive family history (24% versus 19% men), previous urinary infection (31% versus 5%) and structural urinary tract abnormality (14% versus 7%); more men had gout (5% versus 1%) and bladder outlet obstruction (3% versus <1%). Calcium, oxalate and uric acid excretion were increased in 43%, 17% and 22% respectively of men and 31%, 7% and 10% of women. Urinary calcium, oxalate and uric acid correlated significantly, r ranging from 0.149 to 0.311 for 24 h excretion and 0.510 to 0.695 for concentrations per litre. Twenty-two percent of men and 8% of women with normal parathyroid hormone had phosphaturia (excretion of phosphate corrected for glomerular filtration rate (TmPO4/GFR) < 0.70 mmol/L); 6% men and 1.6% women also had low plasma phosphate. Many variables correlated significantly but often weakly with age. Creatinine clearance, pH and (men) TmPO4/GFR decreased from 50 y, urine creatinine, calcium and citrate from 60 y.
Conclusions: Risk factors for stones differ between men and women, change with ageing and in some may have a genetic basis. The role of phosphaturia merits further exploration. | |
dc.publisher | SAGE Publications | |
dc.relation.ispartof | Annals of Clinical Biochemistry | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | calcium nephrolithiasis | |
dc.subject | idiopathic hypercalciuria | |
dc.subject | phosphate leak | |
dc.subject | kidney-stones | |
dc.subject | urinary ph | |
dc.subject | association | |
dc.subject | insights | |
dc.subject | formers | |
dc.subject | disease | |
dc.subject | calculi | |
dc.title | Demography and biochemistry of 2800 patients from a renal stones clinic | |
dc.type | Article | |
dc.identifier.doi | 10.1258/acb.2012.012122 | |
dc.local.publishedsource | http://journals.sagepub.com/doi/pdf/10.1258/acb.2012.012122 | |
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