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dc.contributor.authorTrampush, J W
dc.contributor.authorYang, M L Z
dc.contributor.authorYu, J
dc.contributor.authorKnowles, E
dc.contributor.authorDavies, G
dc.contributor.authorLiewald, D C
dc.contributor.authorStarr, J M
dc.contributor.authorDjurovic, S
dc.contributor.authorMelle, I
dc.contributor.authorSundet, K
dc.contributor.authorChristoforou, A
dc.contributor.authorReinvang, I
dc.contributor.authorDeRosse, P
dc.contributor.authorLundervold, A J
dc.contributor.authorSteen, V M
dc.contributor.authorEspeseth, T
dc.contributor.authorRäikkönen, K
dc.contributor.authorWiden, E
dc.contributor.authorPalotie, A
dc.contributor.authorEriksson, J G
dc.contributor.authorGiegling, I
dc.contributor.authorKonte, B
dc.contributor.authorRoussos, P
dc.contributor.authorGiakoumaki, S
dc.contributor.authorBurdick, K E
dc.contributor.authorPayton, A
dc.contributor.authorOllier, W
dc.contributor.authorHoran, M
dc.contributor.authorChiba-Falek, O
dc.contributor.authorAttix, D K
dc.contributor.authorNeed, A C
dc.contributor.authorCirulli, E T
dc.contributor.authorVoineskos, A N
dc.contributor.authorStefanis, N C
dc.contributor.authorAvramopoulos, D
dc.contributor.authorHatzimanolis, A
dc.contributor.authorArking, D E
dc.contributor.authorSmyrnis, N
dc.contributor.authorBilder, R M
dc.contributor.authorFreimer, N A
dc.contributor.authorCannon, T D
dc.contributor.authorLondon, E
dc.contributor.authorPoldrack, R A
dc.contributor.authorSabb, F W
dc.contributor.authorCongdon, E
dc.contributor.authorConley, E D
dc.contributor.authorScult, M A
dc.contributor.authorDickinson, D
dc.contributor.authorStraub, R E
dc.contributor.authorDonohoe, G
dc.contributor.authorMorris, Derek W.
dc.contributor.authorCorvin, A
dc.contributor.authorGill, M
dc.contributor.authorHariri, A R
dc.contributor.authorWeinberger, D R
dc.contributor.authorPendleton, N
dc.contributor.authorBitsios, P
dc.contributor.authorRujescu, D
dc.contributor.authorLahti, J
dc.contributor.authorLe Hellard, S
dc.contributor.authorKeller, M C
dc.contributor.authorAndreassen, O A
dc.contributor.authorDeary, I J
dc.contributor.authorGlahn, D C
dc.contributor.authorMalhotra, A K
dc.contributor.authorLencz, T
dc.date.accessioned2018-09-20T16:26:54Z
dc.date.available2018-09-20T16:26:54Z
dc.date.issued2017-01-17
dc.identifier.citationTrampush, J W; Yang, M L Z; Yu, J; Knowles, E; Davies, G; Liewald, D C; Starr, J M; Djurovic, S; Melle, I; Sundet, K; Christoforou, A; Reinvang, I; DeRosse, P; Lundervold, A J; Steen, V M; Espeseth, T; Räikkönen, K; Widen, E; Palotie, A; Eriksson, J G; Giegling, I; Konte, B; Roussos, P; Giakoumaki, S; Burdick, K E; Payton, A; Ollier, W; Horan, M; Chiba-Falek, O; Attix, D K; Need, A C; Cirulli, E T; Voineskos, A N; Stefanis, N C; Avramopoulos, D; Hatzimanolis, A; Arking, D E; Smyrnis, N; Bilder, R M; Freimer, N A; Cannon, T D; London, E; Poldrack, R A; Sabb, F W; Congdon, E; Conley, E D; Scult, M A; Dickinson, D; Straub, R E; Donohoe, G; Morris, D; Corvin, A; Gill, M; Hariri, A R; Weinberger, D R; Pendleton, N; Bitsios, P; Rujescu, D; Lahti, J; Le Hellard, S; Keller, M C; Andreassen, O A; Deary, I J; Glahn, D C; Malhotra, A K; Lencz, T (2017). Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium. Molecular Psychiatry 22 (3), 336-345
dc.identifier.issn1359-4184,1476-5578
dc.identifier.urihttp://hdl.handle.net/10379/14191
dc.description.abstractThe complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5x10(-8)). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e. = 0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.
dc.publisherSpringer Nature
dc.relation.ispartofMolecular Psychiatry
dc.subjectgenome-wide association
dc.subjectscottish mental survey
dc.subjectuk biobank n=112151
dc.subjecteducational-attainment
dc.subjectintellectual disability
dc.subjectdevelopmental delay
dc.subjectexecutive function
dc.subjecthuman intelligence
dc.subjectprovides insights
dc.subjectability
dc.titleGwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium
dc.typeArticle
dc.identifier.doi10.1038/mp.2016.244
dc.local.publishedsourcehttp://doi.org/10.1038/mp.2016.244
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