• Login
    ARAN - Access to Research at NUI Galway
    View Item 
    •   ARAN Home
    • Support Services
    • Externally hosted open access publications with NUI Galway authors (2)
    • View Item
    •   ARAN Home
    • Support Services
    • Externally hosted open access publications with NUI Galway authors (2)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ARANCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypesThis CollectionBy Issue DateAuthorsTitlesSubjectsTypes

    My Account

    LoginRegister

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Help

    How to submit and FAQs

    Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium

    Thumbnail
    View/Open
    Full Text
    Date
    2017-01-17
    Author
    Trampush, J W
    Yang, M L Z
    Yu, J
    Knowles, E
    Davies, G
    Liewald, D C
    Starr, J M
    Djurovic, S
    Melle, I
    Sundet, K
    Christoforou, A
    Reinvang, I
    DeRosse, P
    Lundervold, A J
    Steen, V M
    Espeseth, T
    Räikkönen, K
    Widen, E
    Palotie, A
    Eriksson, J G
    Giegling, I
    Konte, B
    Roussos, P
    Giakoumaki, S
    Burdick, K E
    Payton, A
    Ollier, W
    Horan, M
    Chiba-Falek, O
    Attix, D K
    Need, A C
    Cirulli, E T
    Voineskos, A N
    Stefanis, N C
    Avramopoulos, D
    Hatzimanolis, A
    Arking, D E
    Smyrnis, N
    Bilder, R M
    Freimer, N A
    Cannon, T D
    London, E
    Poldrack, R A
    Sabb, F W
    Congdon, E
    Conley, E D
    Scult, M A
    Dickinson, D
    Straub, R E
    Donohoe, G
    Morris, Derek W.
    Corvin, A
    Gill, M
    Hariri, A R
    Weinberger, D R
    Pendleton, N
    Bitsios, P
    Rujescu, D
    Lahti, J
    Le Hellard, S
    Keller, M C
    Andreassen, O A
    Deary, I J
    Glahn, D C
    Malhotra, A K
    Lencz, T
    Metadata
    Show full item record
    Usage
    This item's downloads: 0 (view details)
    Cited 88 times in Scopus (view citations)
    
    Recommended Citation
    Trampush, J W; Yang, M L Z; Yu, J; Knowles, E; Davies, G; Liewald, D C; Starr, J M; Djurovic, S; Melle, I; Sundet, K; Christoforou, A; Reinvang, I; DeRosse, P; Lundervold, A J; Steen, V M; Espeseth, T; Räikkönen, K; Widen, E; Palotie, A; Eriksson, J G; Giegling, I; Konte, B; Roussos, P; Giakoumaki, S; Burdick, K E; Payton, A; Ollier, W; Horan, M; Chiba-Falek, O; Attix, D K; Need, A C; Cirulli, E T; Voineskos, A N; Stefanis, N C; Avramopoulos, D; Hatzimanolis, A; Arking, D E; Smyrnis, N; Bilder, R M; Freimer, N A; Cannon, T D; London, E; Poldrack, R A; Sabb, F W; Congdon, E; Conley, E D; Scult, M A; Dickinson, D; Straub, R E; Donohoe, G; Morris, D; Corvin, A; Gill, M; Hariri, A R; Weinberger, D R; Pendleton, N; Bitsios, P; Rujescu, D; Lahti, J; Le Hellard, S; Keller, M C; Andreassen, O A; Deary, I J; Glahn, D C; Malhotra, A K; Lencz, T (2017). Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium. Molecular Psychiatry 22 (3), 336-345
    Published Version
    http://doi.org/10.1038/mp.2016.244
    Abstract
    The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5x10(-8)). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e. = 0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.
    URI
    http://hdl.handle.net/10379/14191
    Collections
    • Externally hosted open access publications with NUI Galway authors (2)
    • Copyright @ NUI Galway
    • Library
    • NUI Galway