Aliskiren alone or with other antihypertensives in the elderly with borderline and stage 1 hypertension: the apollo trial
Teo, K. K.
MetadataShow full item record
This item's downloads: 0 (view details)
Teo, K. K. Pfeffer, M.; Mancia, G.; O'Donnell, M.; Dagenais, G.; Diaz, R.; Dans, A.; Liu, L.; Bosch, J.; Joseph, P.; Copland, I.; Jung, H.; Pogue, J.; Yusuf, S.; , (2014). Aliskiren alone or with other antihypertensives in the elderly with borderline and stage 1 hypertension: the apollo trial. European Heart Journal 35 (26), 1743-1751
Aims We studied the unclear question whether blood pressure (BP) lowering reduces cardiovascular disease (CVD) in elderly individuals with systolic BP &lt;160 mm Hg. Methods and results We initiated a randomized placebo-controlled stratified 2 x 2 factorial clinical trial evaluating the effects of BP lowering in 11 000 elderly individuals with systolic blood pressure (SBP) between 130 and 159 mm Hg, for 5 years. Following 5-week active run-in, participants were randomized to aliskiren (300 mg) or placebo, and to an additional antihypertensive [hydrochlorothiazide (25 mg) or amlodipine (5 mg)], or their respective placeboes. Study was terminated by sponsor after 1759 subjects (age 72.1 +/- 5.2 years, 88% receiving at least one antihypertensive) were randomized and followed for 0.6 year. Study drugs were well tolerated with few serious adverse events during run-in and after randomization, with no significant differences between treatment groups. By design, three levels of BP reductions were achieved, adjusted mean BP reductions of 3.5/1.7 mm Hg (P &lt; 0.001) by aliskiren, 6.8/3.3 mm Hg (P &lt; 0.001) by hydrochlorothiazide or amlodipine, and 10.3/5.0 mm Hg (P &lt; 0.001) by double therapy compared with placebo. Twenty-five major CVD events occurred. Non-significant trends towards fewer CVD events with greater BP reductions are evident: hazard ratios (HR) 0.82 [95% confidence interval (CI): 0.37-1.81] for 3.5 mm Hg SBP reduction; HR 0.45 (95% CI: 0.19-1.04) for 6.8 mm Hg; and HR 0.25 (0.05-1.18) for 10.3 mm Hg reduction for primary composite of CV death, MI, stroke, or significant heart failure. Conclusions Sizeable reductions in BP, with potential for substantial CVD reduction, can be safely achieved using combinations of BP drugs in the elderly with normal high and Stage 1 hypertension.