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dc.contributor.authorTabrizi, Leila
dc.contributor.authorChiniforoshan, Hossein
dc.date.accessioned2018-09-20T16:26:15Z
dc.date.available2018-09-20T16:26:15Z
dc.date.issued2017-01-01
dc.identifier.citationTabrizi, Leila; Chiniforoshan, Hossein (2017). New cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents. RSC Advances 7 (54), 34160-34169
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/10379/14108
dc.description.abstractA new class of cyclometalated iridium((III)) with NCN pincer and meso-phenylcyanamide BODIPY ligands of the formula [Ir(L)(PPY)(Pcyd-BODIPY)], 1, [Ir(L)(PIQ)(Pcyd-BODIPY)], 2, in which HL: 5-methoxy-1,3-bis (1-methyl-1H-benzo[d]imidazol-2-yl) benzene, Pcyd-BODIPY: 8-(4-phenylcyanamide) BODIPY, PPY: 2-phenylpyridine, PIQ: 1-phenylisoquinoline have been synthesized and studied for photodynamic therapy (PDT). The photophysical properties, DNA binding, DNA photocleavage, cellular uptake, thioredoxin reductase activity, reactive oxygen species (ROS) generation, and cellular apoptosis of the complexes have also been studied. Therefore, we present a conceivable biologically applicable PDT modality that develops persuasively designed photoactivatable Ir((III)) complexes.
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofRSC Advances
dc.subjectcancer-cells
dc.subjectiridium(iii) complexes
dc.subjectpolypyridyl complexes
dc.subjectnickel(ii) complexes
dc.subjectanticancer agents
dc.subjectarene complexes
dc.subjectmetal-complexes
dc.subjectcellular uptake
dc.subjectvisible-light
dc.subjectphotosensitizers
dc.titleNew cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents
dc.typeArticle
dc.identifier.doi10.1039/c7ra05579j
dc.local.publishedsourcehttp://pubs.rsc.org/en/content/articlepdf/2017/ra/c7ra05579j
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