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Ablation of FAP+ stromal cells impairs endogenous revascularization during hind limb ischemia
(NUI Galway, 2020-05-08)
Stromal cells have long been studied for their putative role in maintaining tissue homeostasis,
driving tissue remodeling processes during injury, and modulating inflammation by
synergizing with immune cells. Studying ...
Processing the scientific literature for protein relations (for myocardial infarction) and validation of hypothetical relations through experimental results
(NUI Galway, 2020-02-28)
The last decade has been characterized by a deluge of published scientific literature as well as data generation by biological experiments. The major impediment for the research community to unlock the knowledge contained ...
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)
Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the
tumour and bypass the host immune system. Extracellular Vesicles (EVs) are
thought to be a fingerprint of the parent cell and therefore MSC-EVs ...
Measuring and improving patient safety in general practice in Ireland
(NUI Galway, 2019-11-15)
Due to the large volume of primary care consultations and increasing patient complexity, there is substantial potential for unintentional patient harm. Measuring and monitoring of safety is essential to identify the ...
Diagnostic insights from twenty years of bilateral inferior petrosal sinus sampling for Cushings Disease at Mayo Clinic (1998-2018)
(NUI Galway, 2020-03-02)
Pituitary-dependent Cushing syndrome (CS), referred to herein as Cushing Disease (CD), is the most common cause of endogenous CS. The challenge for diagnosing CD includes difficulty identifying the often small pituitary ...
Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)
Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ...
The Bangladesh National Blindness and Low Vision Survey - Identification of prevalence, causes and the need for eye care services
(NUI Galway, 2019-10-15)
Background:
Bangladesh is a densely populated, impoverished country in South Asia with inadequate health service provision for a variety of diseases including treatable ocular conditions. The aims of this comprehensive ...
The role of the aquatic environment in the spread of antimicrobial resistance of public health significance
(NUI Galway, 2020-02-27)
Antimicrobial resistance (AMR) is one of the greatest threats to human health of the 21st Century, with certain antimicrobial resistant organisms classified as being a greater threat to public health than others. At the ...
Split luciferase reporters of apoptosome formation: a bio-tool to identify new drug-like molecules
(NUI Galway, 2019-12-03)
Formation of apoptosome, a key multiprotein complex in mitochondrial-mediated apoptosis, is an essential step during normal development and deregulation of this event is associated with pathological conditions. The apoptosome ...
USP9X controls DNA replication fork stability and the replication stress checkpoint through Claspin
(2016-02-05)
Cells possess checkpoint pathways which are important for maintaining genome stability and preventing cancer. These signalling pathways include the ATR and CHK1 kinases which are activated in response to DNA damage or ...