Now showing items 1-5 of 5
Synthesis of S-glycolipids and peptidomimetics
Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...
Carbohydrates as precursors to macrocyclic and iminosugar frameworks
Natural products have been perceived as privileged structures in drug discovery based on their evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal chemists to identify some ...
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)
The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ...
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Development and Application of a Computational Method for Determining the Specificity of Glycan-binding Proteins
Changes in cell-surface glycan patterns are markers for the presence of many different disease and cancer types, offering a relatively untapped niche for glycan-targeting reagents and therapeutics in diagnosis and treatment. ...