Now showing items 1-6 of 6
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)
Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ...
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)
This thesis deals with efforts to generate new bioactive organic compounds. The main focus has been on the use of carbohydrate building blocks for synthesis of both macrocyclic compounds and glycoclusters for biological ...
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)
Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ...
Supramolecular ‘Glues’ for protein recognition and assembly
(NUI Galway, 2019-12-06)
Supramolecules such as calixarenes, cucurbiturils and foldamers are rapidly emerging as tools for protein assembly. This thesis builds on past successes with some of these scaffolds. Previously, sulfonato-calixarene was ...
Enhancing the bioavailability of active pharmaceutical ingredients through cocrystallization and coamorphization
(NUI Galway, 2019-12-19)
During drug research and development, improving the solubility of poorly water soluble drugs without chemically modifying the drug molecule is one of the biggest challenges for the pharmaceutical industry. Most medicines ...