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Urothelial carcinoma: Molecular profiling and potential application in clinical practice
(NUI Galway, 2020-02-19)
Urothelial Carcinoma: Molecular Profiling & Potential Application in Clinical Practice
Abstract
Introduction: Urothelial carcinoma is characterised by a tendency to recurrence and risk of progression that necessitates ...
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
(NUI Galway, 2016-02-15)
Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ...
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)
Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ...
Factors influencing diagnosis and outcome in HER2 receptor positive breast cancer
(NUI Galway, 2019-02-22)
Introduction
About 30% of breast cancers are HER2 receptor positive, these breast cancers traditionally had a poor prognosis but the introduction of targeted anti-HER2 therapy (Trastuzumab) has resulted in a vast improvement ...
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)
Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the
tumour and bypass the host immune system. Extracellular Vesicles (EVs) are
thought to be a fingerprint of the parent cell and therefore MSC-EVs ...
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)
Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ...
Optimising endovenous strategies in the management of symptomatic venous incompetence
(NUI Galway, 2021-05-01)
Venous incompetence represents a significant burden of disease globally. In
recent decades the emergence of endovenous ablative techniques have led to a
paradigm shift in the management of venous incompetence. These ...
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
(NUI Galway, 2018-10-19)
Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory
results from using autografts and allografts for hernia repairs. More than fifty years later,
polypropylene is still the most popular ...
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
(NUI Galway, 2022-08-16)
Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ...
Mastectomy and breast reconstruction in the modern era: the role of neoadjuvant therapies and regenerative surgery
(NUI Galway, 2018-10-09)
Complete surgical resection with disease free margins remains the cornerstone of effective breast cancer treatment. Breast cancer management continues to evolve with the development of more sophisticated techniques of ...