Methamphetamine (MA) abuse during pregnancy is a significant concern worldwide. Improving our understanding of the consequences of such exposure on the child is paramount and animal models provide an alternative method of ...

Cells of virtually all organs and tissues are known to release large numbers of subcellular particles called extracellular vesicles (EVs) into bodily fluids such as blood and urine. There has been a growing interest in ...

Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ...

Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ...

The clinical benefits of mesenchymal stromal cell (MSC) based therapies for immune disorders and degenerative diseases are based on their combined ability to modulate the immune system and to differentiate into different ...

SUMMARY UNC-51-like kinase 4 (ULK4) is a novel gene encoding a potential serine/threonine kinase (STK), and little is known about its functions. Limited studies have been carried out so far, and most of the current 12 ...

The focus of this work was to develop and validate in vitro cell culture models of neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease characterized ...

Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ...

Human blood monocytes, recently classified as classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14-CD16++) are reported to be dysregulated in chronic kidney disease (CKD) and may play a role in ...

Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ...