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Now showing items 11-20 of 211
Mesenchymal stromal cells: their immunosuppressive capacity and protein production profile
(2016-08)
The clinical benefits of mesenchymal stromal cell (MSC) based therapies for immune disorders and degenerative diseases are based on their combined ability to modulate the immune system and to differentiate into different ...
Allogeneic cell therapy for osteoarthritis
(2016-05-11)
Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ...
Topics in cocyclic development of pairwise combinatorial designs
(2015-10-14)
This thesis is a compilation of results dealing with cocyclic development of pairwise combinatorial designs. Motivated by a classification of the indexing and extension groups of the Paley Hadamard matrices due to de ...
Maintenance of the spindle assembly checkpoint by PLK1 and CDC7 kinases and characterisation of cell lines carrying mutations in the genes coding for the CDC7 regulatory subunits
(2016-11-15)
The Spindle Assembly Checkpoint (SAC) ensures that accurate chromosome segregation occurs, by preventing progression into anaphase until all kinetochore-microtubule attachments are stable and bi-polar. During a mitotic ...
Roles of a novel serine/threonine protein kinase Ulk4 in mouse brain development and functions
(2016-05-03)
SUMMARY
UNC-51-like kinase 4 (ULK4) is a novel gene encoding a potential serine/threonine kinase (STK), and little is known about its functions. Limited studies have been carried out so far, and most of the current 12 ...
Exosomal microRNAs in colorectal cancer
(2016)
Cancer cells have been shown to release a variety of extracellular membrane vesicles
including microvesicles known as exosomes. Exosomes have recently been found to
contain microRNAs (miRNAs) however the full range within ...
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
(2015-11-05)
Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ...
Methamphetamine exposure during pregnancy: Neurodevelopmental consequences for the offspring
(2016-04-05)
Methamphetamine (MA) abuse during pregnancy is a significant concern worldwide. Improving our understanding of the consequences of such exposure on the child is paramount and animal models provide an alternative method of ...
Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)
Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ...
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)
Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ...