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Now showing items 121-130 of 214
Role of gastro-oesophageal reflux in the development and severity of bronchiectasis
(NUI Galway, 2020-07-30)
Background:
Bronchiectasis is a chronic lung disease associated with significant morbidity and mortality, escalating public health costs and profound reductions in health-related quality of life (QoL). Comorbidity is a ...
Phenotypic and functional properties of HLA-DRhi intermediate monocytes in health and chronic kidney disease
(NUI Galway, 2022-03-25)
Chronic kidney disease (CKD) is a common condition, characteristed by reduced renal
function and frequently associated with progressive loss of glomerular filtration, ultimately
reaching end stage renal disease (ESRD). ...
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
(NUI Galway, 2018-04-13)
There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ...
Human stem cell modelling for heart disease of long QT syndrome
(NUI Galway, 2022-04-29)
Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated ...
Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell applications
(NUI Galway, 2021-08-04)
Chemical compounds synthetized by living organisms have historically contributed to improved human health. Ancient populations made use of local natural products through herbal medicine, which today are to be found as ...
Mastectomy and breast reconstruction in the modern era: the role of neoadjuvant therapies and regenerative surgery
(NUI Galway, 2018-10-09)
Complete surgical resection with disease free margins remains the cornerstone of effective breast cancer treatment. Breast cancer management continues to evolve with the development of more sophisticated techniques of ...
Advances in the management and treatment algorithms for anterior shoulder instability
(NUI Galway, 2022-04-28)
Anterior shoulder instability is a common clinical problem, with a reported incidence ranging from 8 to 25 per 100,000 person years in the general population, with higher rates seen
1-3
in athletic populations.
However, ...
Role of LPS/TLR4 and complement signaling in liver regeneration after partial hepatectomy
(NUI Galway, 2018-04-25)
Liver regeneration after partial hepatectomy (PH) is a complex process involving an inflammatory response that is followed by the proliferation of both parenchymal and nonparenchymal liver cells to restore the lost liver ...
An examination of the effects of viral priming on neurotoxin induced synapse dysfunction and degeneration
(NUI Galway, 2018-10-19)
Over 200 years since its first description, Parkinson’s disease (PD) remains the second most common neurodegenerative disorder. Treatments are insufficient and there is still no cure. The continued lack of treatment ...
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)
Autism spectrum disorders (ASD), include a group of heterogeneous
neurodevelopmental disorders (NDDs) characterized by impaired social interaction,
and communication with restricted patterns of behaviour. The aetiology ...