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Investigation of the therapeutic potential of mesenchymal stem/stromal cells in preclinical models of systemic sepsis
(NUI Galway, 2020-10-29)
Introduction:
Sepsis is a syndrome of life-threatening physiologic, pathologic, and biochemical abnormalities resulting from infection 1. The host immune response, specifically the loss of immune homeostasis induced by ...
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
(NUI Galway, 2018-10-19)
Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory
results from using autografts and allografts for hernia repairs. More than fifty years later,
polypropylene is still the most popular ...
Programmed DNA damage in myogenesis
(2017-02-23)
Skeletal muscle is a major tissue type in humans, comprising approximately 40% of total body mass in adults. Skeletal muscle is ultimately composed of elongated multinucleate cells known as myofibers. These myofibers are ...
A bioinformatic approach to the genetics, human cell models and animal models of autism spectrum disorder
(NUI Galway, 2021-09-17)
Autism Spectrum Disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding the genetic ...
The prognostic and therapeutic value of XBP1 signalling in ER-positive breast cancer
(NUI Galway, 2021-04-02)
Breast cancer is a heterogeneous disease with distinct subtypes having specific molecular features. Approximately, 75% of breast cancers are estrogen receptor α (ER)-positive. Endocrine therapies have been used as a standard ...
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)
Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ...
The role of novel biomarkers in addressing the burden of chronic kidney disease in diabetes mellitus
(NUI Galway, 2022-10-06)
Kidney disease due to diabetes (Diabetic Kidney Disease (DKD)) is the leading cause of chronic kidney disease worldwide. It is an underappreciated, often under-recognised component of the overall burden of diabetes. People ...
The role of sialylation in stromal cell-mediated immunosuppression in the colorectal tumour microenvironment
(NUI Galway, 2023-04-19)
Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of many
immunotherapies. The hypersialylation of cancer cells contributes significantly to this
suppressive environment, aiding in tumour immune ...
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
(NUI Galway, 2022-08-16)
Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ...
Media matters: Impact of expansion media on the phenotype of mesenchymal stromal cells
(NUI Galway, 2023-03-02)
Despite a long history of investigation and sustained efforts in clinical testing with large numbers
of clinical trials being initiated, the number of market authorisations for mesenchymal stromal
cell (MSC) therapies ...