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The cannabinoid type-2 (CB2) receptor as a target for anti-inflammatory disease modification in Parkinson's disease
(2016-08-04)
Parkinson’s disease is a multifaceted neurodegenerative disorder with no curative treatment. A key aspect in the pathogenesis of Parkinson’s disease is inflammation, which is initially triggered by dying neurons and which ...
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)
Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ...
Genotype-dependent responsivity to inflammatory pain: the role of TRPV1 in the periaqueductal grey
(2016-09-21)
The ability to experience pain is essential for survival, and to prevent potential tissue damage upon exposure to noxious stimuli. The periaqueductal grey - rostral ventromedial medulla – dorsal horn of the spinal cord ...
Investigating the epigenetic regulation of toll-like receptor 3
(2017-10-20)
Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ...
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
(NUI Galway, 2018-04-06)
Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ...
The potential of injectable collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2018-10-04)
Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ...
Split luciferase reporters of apoptosome formation: a bio-tool to identify new drug-like molecules
(NUI Galway, 2019-12-03)
Formation of apoptosome, a key multiprotein complex in mitochondrial-mediated apoptosis, is an essential step during normal development and deregulation of this event is associated with pathological conditions. The apoptosome ...
Programmed DNA damage in myogenesis
(2017-02-23)
Skeletal muscle is a major tissue type in humans, comprising approximately 40% of total body mass in adults. Skeletal muscle is ultimately composed of elongated multinucleate cells known as myofibers. These myofibers are ...
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)
Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ...
The role of sialylation in stromal cell-mediated immunosuppression in the colorectal tumour microenvironment
(NUI Galway, 2023-04-19)
Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of many
immunotherapies. The hypersialylation of cancer cells contributes significantly to this
suppressive environment, aiding in tumour immune ...