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Open-source bioelectronics for development of electrochemical biosensors and assays
(NUI Galway, 2019-02-20)
This thesis presents steps in the development of open-source bioelectronics that gather together and combine in the demonstration of a system capable of operating a fully integrated wireless electrochemical biosensor.
Chemical diversity of zoantharians from the coast of Ecuador in the tropical eastern Pacific
(NUI Galway, 2019-09-18)
This thesis describes the isolation and identification of marine natural products from five zoantharian species collected off the Marine Protected Area El Pelado located in Santa Elena, Ecuador. Ecuador is one of the ...
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)
Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ...
Supramolecular ‘Glues’ for protein recognition and assembly
(NUI Galway, 2019-12-06)
Supramolecules such as calixarenes, cucurbiturils and foldamers are rapidly emerging as tools for protein assembly. This thesis builds on past successes with some of these scaffolds. Previously, sulfonato-calix[4]arene was ...
Copper complexes coupled to nucleosides, bile acids and histone deacetylase inhibitors.
(NUI Galway, 2019-12-10)
The aim of this project is to synthesize and characterise novel inorganic complexes which consist of metal-based DNA cleavage entities coupled to biomolecules. It is hoped that the coupling of known DNA cleavage agents to ...
Towards improved performance of mediated glucose oxidising enzyme electrodes for biosensing and biopower applications
(NUI Galway, 2019-11)
Energy produced through enzymatic catalysis at electrodes, namely oxidation of glucose and
reduction of oxygen may be used to power devices. The goal of powering implantable or semiimplantable
medical devices through ...
Control of polymorphism, crystal size and habit in pharmaceuticals
(NUI Galway, 2019-09)
Crystallization is widely used as a purification method of Active Pharmaceutical Ingredients, APIs. During the process a crystalline compound is generally obtained, and it can display general properties and characteristics ...
Enhancing the bioavailability of active pharmaceutical ingredients through cocrystallization and coamorphization
(NUI Galway, 2019-12-19)
During drug research and development, improving the solubility of poorly water soluble drugs without chemically modifying the drug molecule is one of the biggest challenges for the pharmaceutical industry. Most medicines ...
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)
This thesis deals with efforts to generate new bioactive organic compounds. The main focus
has been on the use of carbohydrate building blocks for synthesis of both macrocyclic
compounds and glycoclusters for biological ...