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MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)
Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ...
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)
Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ...
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)
Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the
tumour and bypass the host immune system. Extracellular Vesicles (EVs) are
thought to be a fingerprint of the parent cell and therefore MSC-EVs ...
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
(NUI Galway, 2022-08-16)
Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ...
Extracellular vesicle encapsulated microRNAs and breast cancer
(NUI Galway, 2023-02-24)
Breast cancer is the most prevalent cancer among women worldwide. There
is a clear need for earlier detection methods and more personalised treatments.
Extracellular vesicle encapsulated microRNA (EV-miR) provide novel ...
Current and potential diagnostic modalities in the detection and management of breast cancer
(NUI Galway, 2021-07-06)
Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ...
MicroRNAs for the treatment of breast cancer
(NUI Galway, 2024-01-12)
MicroRNA-379 (miR-379) has been reported as a potent tumour suppressor miRNA
with data supporting a potential therapeutic function in breast cancer. Despite this, the
exact mechanism of action of miR-379 is still ...