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The cannabinoid type-2 (CB2) receptor as a target for anti-inflammatory disease modification in Parkinson's disease
(2016-08-04)
Parkinson’s disease is a multifaceted neurodegenerative disorder with no curative treatment. A key aspect in the pathogenesis of Parkinson’s disease is inflammation, which is initially triggered by dying neurons and which ...
Investigation of the role of nuclear factor kappa-B in mediating the effects of hypercapnic acidosis and mesenchymal stem cells in ventilation induced lung injury
(NUI Galway, 2016-11-08)
Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ...
Developing and characterizing cellular models for neurodegenerative diseases.
(2016-05-13)
The focus of this work was to develop and validate in vitro cell culture models of neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease characterized ...
The role of glycosylation in regulatory T-cell biology
(2016-12-14)
Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. There has been a significant amount of research devoted to understanding their physiological mechanisms of action and the ...
Mesenchymal stromal cells: their immunosuppressive capacity and protein production profile
(2016-08)
The clinical benefits of mesenchymal stromal cell (MSC) based therapies for immune disorders and degenerative diseases are based on their combined ability to modulate the immune system and to differentiate into different ...
Allogeneic cell therapy for osteoarthritis
(2016-05-11)
Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ...
Maintenance of the spindle assembly checkpoint by PLK1 and CDC7 kinases and characterisation of cell lines carrying mutations in the genes coding for the CDC7 regulatory subunits
(2016-11-15)
The Spindle Assembly Checkpoint (SAC) ensures that accurate chromosome segregation occurs, by preventing progression into anaphase until all kinetochore-microtubule attachments are stable and bi-polar. During a mitotic ...
Roles of a novel serine/threonine protein kinase Ulk4 in mouse brain development and functions
(2016-05-03)
SUMMARY
UNC-51-like kinase 4 (ULK4) is a novel gene encoding a potential serine/threonine kinase (STK), and little is known about its functions. Limited studies have been carried out so far, and most of the current 12 ...
Exosomal microRNAs in colorectal cancer
(2016)
Cancer cells have been shown to release a variety of extracellular membrane vesicles
including microvesicles known as exosomes. Exosomes have recently been found to
contain microRNAs (miRNAs) however the full range within ...
Methamphetamine exposure during pregnancy: Neurodevelopmental consequences for the offspring
(2016-04-05)
Methamphetamine (MA) abuse during pregnancy is a significant concern worldwide. Improving our understanding of the consequences of such exposure on the child is paramount and animal models provide an alternative method of ...