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Genetic analysis of ATR, a central regulator of genome stability.
(2016-05-11)
To protect the DNA against the constant assaults of endogenous and environmental agents, cells have developed conserved signaling pathways, known as the DNA damage response. Such responses are important to maintain genome ...
Pro-survival pathways in triple negative breast cancer: Focus on the roles of RIP2 and HSPB1
(2016-10-10)
Triple negative breast cancers (TNBC) lack estrogen and progesterone receptors, and HER-2 markers rendering them resistant to current targeted therapies. Most TNBCs show basal-like characteristics and the terms TNBC and ...
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
(2017-10-31)
Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ...
Decoy Receptors block tumour cell eradication by TRAIL - Molecular engineering of TRAIL to evade decoy receptors
(2012-06-29)
Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine expressed by immune cells which selectively eradicates a wide range of cancer cells while leaving normal healthy cells unharmed. TRAIL binds ...
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
(2016-02-08)
CDC7 is an essential serine/threonine kinase required for the initiation of DNA
replication in eukaryotic cells, through phosphorylating the MCM helicase complex.
Formation of an active kinase requires the binding to ...
RNA metabolism proteins identified as ATM and 53BP1 partners function in the DDR
(2017-07-05)
The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ...
NGF/p75NTR or HSPB1-mediated regulation of cell survival under stress
(2016-02-09)
Triple negative breast cancers (TNBC) lack estrogen, progesterone and HER-2 receptors rendering them insensitive to current hormone targeted therapies. However, TNBC have been reported to express and secrete an additional ...
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
(2015-09-18)
X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response
(UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress.
Activation of the endoplasmic reticulum ...
Mapping protein architecture in centromeres of Equus asinus
(2016-11-28)
The centromere is a genetic locus present once per chromosome that specifies the site
of kinetochore formation and is vital for chromosomal segregation. With the
exception of Saccharomyces cerevisiae, whose ‘point’ ...
Contribution of non-histone proteins to chromatin structure and stability
(2015-10-30)
Histones are responsible for packaging the genomes of almost all eukaryotes into fundamental repeating nucleosome units. The packaging must facilitate compaction into the cell nucleus but also enable dynamic access to the ...