Browsing NUI Galway Theses (PhD Theses) by Title
Now showing items 493-512 of 1119
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'I'm not going to be able to leave'; The impact of belonging to the Irish farming community on university students' life experiences and transitions to adulthood
(2014-02-10)Despite extensive research into family farming culture little attention has been paid to young people raised in this community who do not become full-time farmers. This thesis explores the childhood experiences of university ... -
I-Ulysses: poetry in motion. An educational virtual reality guide to the unfolding events of the ‘Wandering Rocks’ chapter of Joyce’s Ulysses.
(2016-01-29)A spatial and temporal virtual reality experience, guiding the user through the unfolding events of the ‘Wandering Rocks’ chapter of James Joyce’s Ulysses. This is an educational tool intended to help the user understand ... -
Identification and analysis of polymorphisms in miRNA genes and associated targets in Bos taurus and Bos primigenius for genomic selection in cattle
(2017-02-21)Cattle production is of high economic importance to agriculture in Ireland. For more than a decade, significant effort focused on the improvement of the selection of economically important traits in beef and dairy breeds. ... -
Identification and characterization of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
(2017-03-24)Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ... -
Identification of bioactive natural products after screening Irish marine bio-resources
(2016-10-21)According to the “Real Map of Ireland” published by Marine Institute, Ireland, the Nation marine territory has ten times more area than its land mass. Despite the well-studied and reported biodiversity present in Irish ... -
Identification of compounds that may be repurposed for the treatment of triple negative breast cancer
(2012-11-21)Triple negative breast cancers (TNBC), lack the estrogen and progesterone receptors as well as the HER2 receptor. Currently, there is no selective therapy for the treatment of TNBC and current treatment regimens rely on a ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
(2016-02-08)CDC7 is an essential serine/threonine kinase required for the initiation of DNA replication in eukaryotic cells, through phosphorylating the MCM helicase complex. Formation of an active kinase requires the binding to ... -
Identification of novel drug combinations for haematological malignancies
(2015-01-29)TNF-related apoptosis ligand (TRAIL) is a tumour selective cytokine with potential anti-cancer activity which is currently in clinical trials. Haematological malignancies along with several other cancers have showed varied ... -
Identification of novel factors that promote trinucleotide repeat instability
(2013-09-23)Trinucleotide repeat (TNR) expansions are the genetic cause of several inherited neurological diseases. Factors that affect the propensity of TNRs to expand include the characteristics of the TNR DNA, the chromatin ... -
Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies
(2011-12-16)Advances in our understanding of the molecular mechanisms underlying breast cancer are leading to improvements in its management. Many of the recent gene-based signatures developed for breast cancer have highlighted the ... -
Identifying novel strategies to re-engage the apoptotic pathway for the treatment of cancer
(2014-09-30)In chapter two we demonstrate that in non-transformed cells multiple signalling pathways control TRAIL resistance and they act in a redundant manner. This is contrary, however, to the resistance mechanisms found in tumour ... -
Identifying, annotating, and filtering arguments and opinions in open collaboration systems
(2013-09-13)The World Wide Web enables large-scale collaboration, even between groups of individuals previously unknown to one another. These collaborations produce tangible outputs, such as encyclopedias (Wikipedia), electronic books ... -
Identity Formation Among Teenaged Members of the Muslim Population of Ballyhaunis, Co. Mayo
(2012-08-29)Younger members of Muslim populations in Western society are placed at the frontline of the immigration process. As a result of daily school attendance and exposure to the media they are often heavily influenced by the ... -
Illegal territoriality in international law: the interaction and enforcement of the law of belligerant occupation through other territorial regimes
(2014-08-30)This work examines the place and function of the international law of belligerent occupation its interplays with other public international law regimes and argues that the co-application of these regimes, as well as an ... -
Image and video quality in the automotive environment
(2016-05-12)This thesis is concerned with the development of methodologies for image and video quality assessment for the automotive environment, and the use of those methodologies for evaluating the effect of image and video ... -
Images and representations of the sea in early medieval Hiberno-Latin and vernacular literature: studies in intertextuality and innovation
(2017-02-23)This research takes the sea and its creatures as the common focus for an investigation of a series of thematically linked early medieval texts’ interactions with each other and with texts ranging from contemporaneous Insular ... -
Immunogenicity of allogeneic mesenchymal stem cells
(2016-10-20)Allogeneic mesenchymal stem cells (allo-MSC) are a promising “off-the-shelf” therapy and are often cited as failing to elicit anti-donor immune responses. Intra-muscular (IM) administration may be the optimal route for ... -
Immunomodulation by interleukin-10 overexpressing mesenchymal stem cells for cartilage repair in osteoarthritis
(2015-03-06)Although osteoarthritis (OA) is typically characterised by the loss or damage to articular cartilage, inflammation of the synovial membrane is now recognised as a prevalent feature believed to contribute to both symptoms ... -
Immunomodulation of the T-helper 17 Cell Lineage by Mesenchymal Stem Cells
(2012-11-20)T-helper 17 (Th17) cells play a pathogenic role in multiple sclerosis, inflammatory bowel disease, psoriasis, acute kidney injury, glomerulonephritis and transplant rejection. Mesenchymal stem cells (MSCs) are immunosuppressive ...