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dc.contributor.authorStevens, K. N.
dc.contributor.authorFredericksen, Z.
dc.contributor.authorVachon, C. M.
dc.contributor.authorWang, X.
dc.contributor.authorMargolin, S.
dc.contributor.authorLindblom, A.
dc.contributor.authorNevanlinna, H.
dc.contributor.authorGreco, D.
dc.contributor.authorAittomaki, K.
dc.contributor.authorBlomqvist, C.
dc.contributor.authorChang-Claude, J.
dc.contributor.authorVrieling, A.
dc.contributor.authorFlesch-Janys, D.
dc.contributor.authorSinn, H.-P.
dc.contributor.authorWang-Gohrke, S.
dc.contributor.authorNickels, S.
dc.contributor.authorBrauch, H.
dc.contributor.authorKo, Y.-D.
dc.contributor.authorFischer, H.-P.
dc.contributor.authorSchmutzler, R. K.
dc.contributor.authorMeindl, A.
dc.contributor.authorBartram, C. R.
dc.contributor.authorSchott, S.
dc.contributor.authorEngel, C.
dc.contributor.authorGodwin, A. K.
dc.contributor.authorWeaver, J.
dc.contributor.authorPathak, H. B.
dc.contributor.authorSharma, P.
dc.contributor.authorBrenner, H.
dc.contributor.authorMuller, H.
dc.contributor.authorArndt, V.
dc.contributor.authorStegmaier, C.
dc.contributor.authorMiron, P.
dc.contributor.authorYannoukakos, D.
dc.contributor.authorStavropoulou, A.
dc.contributor.authorFountzilas, G.
dc.contributor.authorGogas, H. J.
dc.contributor.authorSwann, R.
dc.contributor.authorDwek, M.
dc.contributor.authorPerkins, A.
dc.contributor.authorMilne, R. L.
dc.contributor.authorBenitez, J.
dc.contributor.authorZamora, M. P.
dc.contributor.authorPerez, J. I. A.
dc.contributor.authorBojesen, S. E.
dc.contributor.authorNielsen, S. F.
dc.contributor.authorNordestgaard, B. G.
dc.contributor.authorFlyger, H.
dc.contributor.authorGuenel, P.
dc.contributor.authorTruong, T.
dc.contributor.authorMenegaux, F.
dc.contributor.authorCordina-Duverger, E.
dc.contributor.authorBurwinkel, B.
dc.contributor.authorMarme, F.
dc.contributor.authorSchneeweiss, A.
dc.contributor.authorSohn, C.
dc.contributor.authorSawyer, E.
dc.contributor.authorTomlinson, I.
dc.contributor.authorKerin, M. J.
dc.contributor.authorPeto, J.
dc.contributor.authorJohnson, N.
dc.contributor.authorFletcher, O.
dc.contributor.authordos Santos Silva, I.
dc.contributor.authorFasching, P. A.
dc.contributor.authorBeckmann, M. W.
dc.contributor.authorHartmann, A.
dc.contributor.authorEkici, A. B.
dc.contributor.authorLophatananon, A.
dc.contributor.authorMuir, K.
dc.contributor.authorPuttawibul, P.
dc.contributor.authorWiangnon, S.
dc.contributor.authorSchmidt, M. K.
dc.contributor.authorBroeks, A.
dc.contributor.authorBraaf, L. M.
dc.contributor.authorRosenberg, E. H.
dc.contributor.authorHopper, J. L.
dc.contributor.authorApicella, C.
dc.contributor.authorPark, D. J.
dc.contributor.authorSouthey, M. C.
dc.contributor.authorSwerdlow, A. J.
dc.contributor.authorAshworth, A.
dc.contributor.authorOrr, N.
dc.contributor.authorSchoemaker, M. J.
dc.contributor.authorAnton-Culver, H.
dc.contributor.authorZiogas, A.
dc.contributor.authorBernstein, L.
dc.contributor.authorDur, C. C.
dc.contributor.authorShen, C.-Y.
dc.contributor.authorYu, J.-C.
dc.contributor.authorHsu, H.-M.
dc.contributor.authorHsiung, C.-N.
dc.contributor.authorHamann, U.
dc.contributor.authorDunnebier, T.
dc.contributor.authorRudiger, T.
dc.contributor.authorUlmer, H. U.
dc.contributor.authorPharoah, P. P.
dc.contributor.authorDunning, A. M.
dc.contributor.authorHumphreys, M. K.
dc.contributor.authorWang, Q.
dc.contributor.authorCox, A.
dc.contributor.authorCross, S. S.
dc.contributor.authorReed, M. W.
dc.contributor.authorHall, P.
dc.contributor.authorCzene, K.
dc.contributor.authorAmbrosone, C. B.
dc.contributor.authorAdemuyiwa, F.
dc.contributor.authorHwang, H.
dc.contributor.authorEccles, D. M.
dc.contributor.authorGarcia-Closas, M.
dc.contributor.authorFigueroa, J. D.
dc.contributor.authorSherman, M. E.
dc.contributor.authorLissowska, J.
dc.contributor.authorDevilee, P.
dc.contributor.authorSeynaeve, C.
dc.contributor.authorTollenaar, R. A. E. M.
dc.contributor.authorHooning, M. J.
dc.contributor.authorAndrulis, I. L.
dc.contributor.authorKnight, J. A.
dc.contributor.authorGlendon, G.
dc.contributor.authorMulligan, A. M.
dc.contributor.authorWinqvist, R.
dc.contributor.authorPylkas, K.
dc.contributor.authorJukkola-Vuorinen, A.
dc.contributor.authorGrip, M.
dc.contributor.authorJohn, E. M.
dc.contributor.authorMiron, A.
dc.contributor.authorAlnaes, G. G.
dc.contributor.authorKristensen, V.
dc.contributor.authorBorresen-Dale, A.-L.
dc.contributor.authorGiles, G. G.
dc.contributor.authorBaglietto, L.
dc.contributor.authorMcLean, C. A.
dc.contributor.authorSeveri, G.
dc.contributor.authorKosel, M. L.
dc.contributor.authorPankratz, V. S.
dc.contributor.authorSlager, S.
dc.contributor.authorOlson, J. E.
dc.contributor.authorRadice, P.
dc.contributor.authorPeterlongo, P.
dc.contributor.authorManoukian, S.
dc.contributor.authorBarile, M.
dc.contributor.authorLambrechts, D.
dc.contributor.authorHatse, S.
dc.contributor.authorDieudonne, A.-S.
dc.contributor.authorChristiaens, M.-R.
dc.contributor.authorChenevix-Trench, G.
dc.contributor.authorBeesley, J.
dc.contributor.authorChen, X.
dc.contributor.authorMannermaa, A.
dc.contributor.authorKosma, V.-M.
dc.contributor.authorHartikainen, J. M.
dc.contributor.authorSoini, Y.
dc.contributor.authorEaston, D. F.
dc.contributor.authorCouch, F. J.
dc.contributor.author,
dc.contributor.author,
dc.contributor.author,
dc.date.accessioned2018-09-20T16:25:33Z
dc.date.available2018-09-20T16:25:33Z
dc.date.issued2012-02-13
dc.identifier.citationStevens, K. N. Fredericksen, Z.; Vachon, C. M.; Wang, X.; Margolin, S.; Lindblom, A.; Nevanlinna, H.; Greco, D.; Aittomaki, K.; Blomqvist, C.; Chang-Claude, J.; Vrieling, A.; Flesch-Janys, D.; Sinn, H.-P.; Wang-Gohrke, S.; Nickels, S.; Brauch, H.; Ko, Y.-D.; Fischer, H.-P.; Schmutzler, R. K.; Meindl, A.; Bartram, C. R.; Schott, S.; Engel, C.; Godwin, A. K.; Weaver, J.; Pathak, H. B.; Sharma, P.; Brenner, H.; Muller, H.; Arndt, V.; Stegmaier, C.; Miron, P.; Yannoukakos, D.; Stavropoulou, A.; Fountzilas, G.; Gogas, H. J.; Swann, R.; Dwek, M.; Perkins, A.; Milne, R. L.; Benitez, J.; Zamora, M. P.; Perez, J. I. A.; Bojesen, S. E.; Nielsen, S. F.; Nordestgaard, B. G.; Flyger, H.; Guenel, P.; Truong, T.; Menegaux, F.; Cordina-Duverger, E.; Burwinkel, B.; Marme, F.; Schneeweiss, A.; Sohn, C.; Sawyer, E.; Tomlinson, I.; Kerin, M. J.; Peto, J.; Johnson, N.; Fletcher, O.; dos Santos Silva, I.; Fasching, P. A.; Beckmann, M. W.; Hartmann, A.; Ekici, A. B.; Lophatananon, A.; Muir, K.; Puttawibul, P.; Wiangnon, S.; Schmidt, M. K.; Broeks, A.; Braaf, L. M.; Rosenberg, E. H.; Hopper, J. L.; Apicella, C.; Park, D. J.; Southey, M. C.; Swerdlow, A. J.; Ashworth, A.; Orr, N.; Schoemaker, M. J.; Anton-Culver, H.; Ziogas, A.; Bernstein, L.; Dur, C. C.; Shen, C.-Y.; Yu, J.-C.; Hsu, H.-M.; Hsiung, C.-N.; Hamann, U.; Dunnebier, T.; Rudiger, T.; Ulmer, H. U.; Pharoah, P. P.; Dunning, A. M.; Humphreys, M. K.; Wang, Q.; Cox, A.; Cross, S. S.; Reed, M. W.; Hall, P.; Czene, K.; Ambrosone, C. B.; Ademuyiwa, F.; Hwang, H.; Eccles, D. M.; Garcia-Closas, M.; Figueroa, J. D.; Sherman, M. E.; Lissowska, J.; Devilee, P.; Seynaeve, C.; Tollenaar, R. A. E. M.; Hooning, M. J.; Andrulis, I. L.; Knight, J. A.; Glendon, G.; Mulligan, A. M.; Winqvist, R.; Pylkas, K.; Jukkola-Vuorinen, A.; Grip, M.; John, E. M.; Miron, A.; Alnaes, G. G.; Kristensen, V.; Borresen-Dale, A.-L.; Giles, G. G.; Baglietto, L.; McLean, C. A.; Severi, G.; Kosel, M. L.; Pankratz, V. S.; Slager, S.; Olson, J. E.; Radice, P.; Peterlongo, P.; Manoukian, S.; Barile, M.; Lambrechts, D.; Hatse, S.; Dieudonne, A.-S.; Christiaens, M.-R.; Chenevix-Trench, G.; Beesley, J.; Chen, X.; Mannermaa, A.; Kosma, V.-M.; Hartikainen, J. M.; Soini, Y.; Easton, D. F.; Couch, F. J.; , ; , ; , (2012). 19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Research 72 (7), 1795-1803
dc.identifier.issn0008-5472,1538-7445
dc.identifier.urihttp://hdl.handle.net/10379/14018
dc.description.abstractThe 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. Here, we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 OR, 1.10; 95% confidence interval (CI), 1.05-1.15; P = 3.49 x 10(-5)] and triple-negative (ER-, PR-, and HER2-negative) breast cancer (rs8170: OR, 1.22; 95% CI, 1.13-1.31; P = 2.22 x 10(-7)). However, rs8170 was no longer associated with ER-negative breast cancer risk when triple-negative cases were excluded (OR, 0.98; 95% CI, 0.89-1.07; P = 0.62). In addition, a combined analysis of triple-negative cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC; N = 3,566) identified a genome-wide significant association between rs8170 and triple-negative breast cancer risk (OR, 1.25; 95% CI, 1.18-1.33; P = 3.31 x 10-(13)]. Thus, 19p13.1 is the first triple-negativespecific breast cancer risk locus and the first locus specific to a histologic subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple-negative tumors and other subtypes likely arise through distinct etiologic pathways. Cancer Res; 72(7); 1795-803. (C)2012 AACR.
dc.publisherAmerican Association for Cancer Research (AACR)
dc.relation.ispartofCancer Research
dc.subjectgenome-wide association
dc.subjectcommon variants
dc.subjectrisk-factors
dc.subjectconfer susceptibility
dc.subject14q24.1 rad51l1
dc.subjecttumor subtypes
dc.subjectbrca1
dc.subjectpopulation
dc.subjectconsortium
dc.subjectcomplex
dc.title19p13.1 is a triple-negative-specific breast cancer susceptibility locus
dc.typeArticle
dc.identifier.doi10.1158/0008-5472.can-11-3364
dc.local.publishedsourcehttp://cancerres.aacrjournals.org/content/canres/72/7/1795.full.pdf
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