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Now showing items 61-70 of 114
Preclinical assessment of the novel compound EL102 in prostate cancer
(2015-03-31)
Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ...
The prevalence of abnormal glucose tolerance up to 5 years after an index pregnancy complicated by gestational diabetes defined using International Association of Diabetes and Pregnancy Study Groups criteria
(2015-09-25)
Introduction
Gestational diabetes (GDM) is associated with an increased future risk of type 2 diabetes, but the risk among women diagnosed with the International Association of Diabetes and Pregnancy Study Groups (IADPSG) ...
Endocannabinoid modulation of TLR4-induced neuroinflammation: implications for autism spectrum disorders
(2014-07-07)
Neuroinflammation is a key component of various neurological diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis and psychiatric and neurodevelopmental disorders such as depression and autism. ...
The effects of anti-TNFα antibody therapy on peripheral blood mononuclear cells in patients with inflammatory bowel disease
(2015-09-30)
Monocytes, recently classified as CD14++CD16- (classical), CD14++CD16+ (intermediate) and CD14dimCD16++ (non-classical) are considered to play a role in the pathogenesis of inflammatory bowel diseases (IBD). Anti-tumor ...
Stem cell modelling for the role of NRXN1 deletion in Autism Spectrum Disorder
(NUI Galway, 2018-12-21)
Autism spectrum disorder (ASD), a multi-factorial disease, often has co-morbidity with epilepsy, which is associated with excessive neuronal firing. The pre-synaptic protein Neurexin1 (NRXN1) signals bi-directionally through ...
Statistical and geographic analysis of out-of-hospital cardiac arrest using registry data
(NUI Galway, 2018-10-08)
Background: Out-of-hospital cardiac arrest (OHCA) is the most critical health event that occurs in the community. When the heart stops pumping blood, if resuscitation is not started, biological death will occur within ...
An analysis of the health risks associated with international travel
(2015-01-28)
This thesis, submitted for the award of a doctoral degree in Medicine, represents an attempt to collate all of my original research projects in travel medicine completed at NUI Galway. Chapter 1 presents four projects ...
Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences
(2013-08-28)
Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor for ischaemic stroke, associated with a five-fold increase in risk. ...
Investigation of the Role of the NF-kB Pathway in Mediating the Effects of Hypercapnic Acidosis in Prolonged Systemic Sepsis and Ventilation Induced Acute Lung Injury
(2012-11)
Background: Lung protective ventilation is integral to the management of ARDS. The resulting respiratory acidosis [HCA], termed 'permissive hypercapnia', is protective in diverse non-septic acute lung injury [ALI] models, ...
Diet and renal outcomes
(2014-11)
Chronic Kidney Disease (defined by decreased glomerular filtration rate and proteinuria) is associated with significant morbidity, increased cardiovascular risk and premature mortality. Advanced chronic kidney disease, ...