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Chemical diversity of zoantharians from the coast of Ecuador in the tropical eastern Pacific
(NUI Galway, 2019-09-18)
This thesis describes the isolation and identification of marine natural products from five zoantharian species collected off the Marine Protected Area El Pelado located in Santa Elena, Ecuador. Ecuador is one of the ...
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)
Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ...
An optical investigation into post compression aerodynamics in a dual opposed piston rapid compression machine
(NUI Galway, 2020-02-07)
Experimental chemical kineticists use rapid compression machines (RCMs) to verify models of global reactivity of fuels in as an ideal environment as possible, similar to those experienced in internal combustion engines. ...
Supramolecular ‘Glues’ for protein recognition and assembly
(NUI Galway, 2019-12-06)
Supramolecules such as calixarenes, cucurbiturils and foldamers are rapidly emerging as tools for protein assembly. This thesis builds on past successes with some of these scaffolds. Previously, sulfonato-calix[4]arene was ...
Chemical diversity of some benthic cyanobacteria from French Polynesia and New Caledonia
(NUI Galway, 2020-08-04)
Cyanobacteria are often considered proliferative in relation with the global change affecting oceans worldwide and especially in the coral reefs of the Pacific Ocean. The bloom of the cyanobacteria in the Pacific Ocean are ...
Experimental studies of simple hydrocarbons in a shock tube
(NUI Galway, 2020-09-24)
Chemical kinetic models are needed to simulate fuel chemistry in combustion devices and to aid
in the development of new designs to reduce harmful emissions and maximize combustor performance.
However, these models need ...
Characterisation of bovine pericardium and alternative treatments for its application as biomaterial
(NUI Galway, 2020-04-09)
Bovine pericardium is an extensively used biomaterial utilised in a wide range
of biomedical devices such as bioprosthetic heart valves. The characterisation
techniques employed for the analysis of bovine pericardium and ...
Copper complexes coupled to nucleosides, bile acids and histone deacetylase inhibitors.
(NUI Galway, 2019-12-10)
The aim of this project is to synthesize and characterise novel inorganic complexes which consist of metal-based DNA cleavage entities coupled to biomolecules. It is hoped that the coupling of known DNA cleavage agents to ...
Towards improved performance of mediated glucose oxidising enzyme electrodes for biosensing and biopower applications
(NUI Galway, 2019-11)
Energy produced through enzymatic catalysis at electrodes, namely oxidation of glucose and
reduction of oxygen may be used to power devices. The goal of powering implantable or semiimplantable
medical devices through ...
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) for the analysis of Immunoglobulin G (IgG) type proteins
(NUI Galway, 2020-10-02)
Immunoglobulin G (IgG) is the main antibody used in the biopharmaceutical industry for therapeutic purposes. Monoclonal antibodies (mAb) are growing in the marked due to its high specificity and safety. Physical and ...