Now showing items 21-25 of 25
Stem cell modelling for the role of NRXN1 deletion in Autism Spectrum Disorder
(NUI Galway, 2018-12-21)
Autism spectrum disorder (ASD), a multi-factorial disease, often has co-morbidity with epilepsy, which is associated with excessive neuronal firing. The pre-synaptic protein Neurexin1 (NRXN1) signals bi-directionally through ...
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)
Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ...
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)
NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ...
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)
Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ...
Evaluation of the efficacy of the Baska Mask
(NUI Galway, 2018-03-22)
The Baska mask is a new supraglottic airway device (SAD). Its novel features include a non-inflatable cuff consisting of a silicone membrane, and an oesophageal drainage system with sump reservoir, connected to 2 drainage ...