Search
Now showing items 91-100 of 219
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)
Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ...
An investigation of the role of the hypersialylated myeloma cell surface in facilitating evasion of natural killer cell-mediated immunosurveillance
(NUI Galway, 2021-12-30)
Abnormal glycosylation is a hallmark of cancer, and hypersialylation in particular has been shown to facilitate abnormal cell trafficking and drug resistance in many cancers, including Multiple Myeloma (MM) - a currently ...
Feasibility of mesenchmyal stem cells as modulators of inflammation and as a cellular model to study cartilage damage in osteoarthritis
(NUI Galway, 2020-04-10)
Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ...
Adaptive clinical trials of sodium lowering in chronic kidney disease and dialysis: Analytic and methodologic challenges
(NUI Galway, 2022-04-24)
The incidence and prevalence of kidney failure requiring dialysis is rising. Patients receiving dialysis are at increased cardiovascular risk, compared to the general population. Hypertension due to sodium and volume excess ...
Impact of interventions for obesity on insulin sensitivity using the leptin to adiponectin ratio
(NUI Galway, 2021-11-13)
Introduction:
Low energy meal replacement regimens can induce short-term weight loss in patients with severe obesity, but usually require specially formulated dietary supplements. Hypocaloric diets are known to induce ...
The role of glycosylation in intervertebral disc degeneration: Towards glyco-functionalised therapeutics
(NUI Galway, 2021-09-24)
Low back pain (LBP) is a common health issue that imposes a significant socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the major contributing causes of LBP. It is initiated by altered ...
Importance of the caregiver in lifestyle interventions for cognitive impairment
(NUI Galway, 2022-04-11)
Lifestyle risk factors have been identified as key targets for dementia prevention strategies, with most clinical trials targeting individual-level interventions. However, many lifestyle behaviours are known to cluster ...
Changes in anthropometric and metabolic outcomes during and after a milk-based meal replacement programme in bariatric patients
(NUI Galway, 2020-04-14)
During this work, I examined a cohort of patients with severe and complicated obesity undergoing a milk-based intensive weight management programme, examining changes in various traits in the short and medium term.
Firstly, ...
Subtotal ablation and hyperthermia in the adrenal cortex
(NUI Galway, 2021-08)
Primary aldosteronism (PA) accounts for 5–12% of all hypertension and confers a higher risk for cardiovascular and cerebrovascular complications compared to age and blood pressure (BP) matched essential hypertension. PA ...
A qualitative exploration of the factors that influence healthcare decision-making in the management of end stage renal disease in older adults in Ireland.
(NUI Galway, 2021-12-10)
Background
Older patients with end-stage renal disease (ESRD) are willing participants in advance care planning
(ACP) but just over 10% engage in it (1-3), potentially as nephrologists fear such conversations may
upset ...