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The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
(2016-07-08)
Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ...
Marine biodiscovery from Floridian mangrove forests and Irish waters
(2017-08-23)
Natural products have been used since ancient times to treat illnesses and terrestrial organisms have been studied extensively from a chemical point of view. Marine organisms, on the other hand are definitely understudied ...
A study of factors influencing anomerisation reactions
(2016-07-18)
This thesis involves an investigation into the anomerisation reaction and strategies by which the reaction can potentially be improved and provide a greater understanding of factors influencing the reaction. There has been ...
The use of supported photomediators in the generation of carbon radicals for synthetic purposes
(2012-11-05)
Carbon-carbon bond formation is a key step in synthetic organic chemistry and there are many methods available for carrying it out, a number of which involve the use of carbon radicals. Many methods however involve the use ...
Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide
(NUI Galway, 2018-10-15)
Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these ...
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)
The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in
carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers
a facile method to generate 1,2-cis ...
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)
This thesis deals with efforts to generate new bioactive organic compounds. The main focus
has been on the use of carbohydrate building blocks for synthesis of both macrocyclic
compounds and glycoclusters for biological ...
Heterocyclic chemistry: Controlled unmasking of nitric oxide and nitroxides
(NUI Galway, 2019-11-29)
Nitric oxide (NO) is a gaseous free radical with medicinally significant properties. The NO-releasing prodrug, isosorbide-5-mononitrate (Is5N), is long established for the treatment of angina pectoris. Nitroxides are organic ...
Small-molecule-based crosslinking and bioconjugation of biomolecules
(NUI Galway, 2020-01-10)
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging area of chemical biology. The superior nucleophilicity of cysteine presents it as a uniquely reactive bioconjugation handle. ...