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Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
(2017-10-31)
Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ...
RNA metabolism proteins identified as ATM and 53BP1 partners function in the DDR
(2017-07-05)
The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ...
Nucleosome organisation and CENP-C distribution at satellite-free centromeres in Equus asinus
(2017-02-15)
Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ...
Characterisation of core histone sequences and nuclear mobility using a reproducible research approach
(2017-09-19)
Chromatin is a dynamic complex that controls access to genetic information by undergoing structural reconfigurations. Understanding this dynamic can provide insights into the biological implications of chromatin ...
A refined model of nucleolar formation derived from the analysis of UBF variants and the hierarchical silencing of human nucleolar organizer regions
(NUI Galway, 2017-03-23)
The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed nucleolar organizer regions (NORs). As the site of ribosome biogenesis, nucleolar function is intrinsically linked to ...
Inhibition of polyomavirus DNA replication by nucleotide analogs
(2017-01-31)
Polyomaviruses are non-evenloped circular DNA viruses that cause severe polyomavirus-associated diseases in immune compromised individuals. The diseases associated with these viruses have been on the rise due to myriad of ...
Molecular determinants of CTG.CAG repeat expansions in Huntington's disease
(2017-10)
CTG•CAG repeat expansions are the underlying genetic cause for at least 12
inherited neurological disorders, including Huntington’s disease (HD) and myotonic
dystrophy type I (DM1). Trinucleotide repeats (TNRs) are very ...
The lysine acetyltransferase MOF: its interactome, role in breast cancer, and characterisation of a novel isoform
(2017-11-24)
Males absent on the first (MOF), also known as hMOF, MYST1, or KAT8, is a lysine
acetyltransferase responsible for bulk acetylation of Histone H4 at lysine 16 (H4K16ac),
though it has also been shown to acetylate several ...