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The role of matrix properties and extrinsic loading in osteoblast-osteocyte differentiation in tissue engineered scaffolds
(2018-02-05)
Bone tissue engineering is a promising field with the potential to generate tissue substitutes, by taking advantage of mesenchymal stem cells ability to grow and produce tissue substitutes under specific physical conditions. ...
The influence of collagen isolation, cross-linking and sterilisation on macrophage response
(2018-03-07)
Collagen-based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue, isolation protocol) and post- (e.g. cross-linking, scaffold architecture, sterilisation) ...
Carbon fibre reinforced PEEK laminated as a material for orthopaedic devices: An experimental and computational investigation
(NUI Galway, 2018-11-27)
The overall objective of this thesis is to investigate carbon fibre reinforced poly-ether-ether-ketone (PEEK) laminates as a material for fracture fixation devices through a combination of experimental testing and computational ...
A thermodynamically motivated investigation of cell and tissue remodelling
(NUI Galway, 2018-08-24)
The overall objective of this thesis is to provide a new understanding of the mechanisms that drive cell spreading and remodelling, and to extend this understanding to remodelling at a tissue and organ level.
A steady-state ...
Analysis of the mechanical performance of a biodegradable magnesium stent in a remodelling artery
(NUI Galway, 2018-09-28)
Coronary stents made from degradable biomaterials such as magnesium alloy are an emerging technology in the treatment of coronary artery disease. Biodegradable stents provide mechanical support to the artery during the ...