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The investigation of methylmagnesium chloride as a non-nucleophilic base
(NUI Galway, 2018-11-30)
The use of methylmagnesium chloride (MeMgCl) as a non-nucleophilic base is explored in this thesis.
Grignard reagents react in nucleophilic addition reactions with nitriles yielding a ketone upon work-up, but in the ...
Combustion kinetic studies of future transportation fuels and intermediates
(NUI Galway, 2020-10-22)
The transportation sector requires an abundant supply of fossil and/or bio-derived fuels,
which all produce significant quantities of greenhouse gas (GHG) emissions. The
transportation sector is expected to account for ...
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)
Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ...
Supramolecular ‘Glues’ for protein recognition and assembly
(NUI Galway, 2019-12-06)
Supramolecules such as calixarenes, cucurbiturils and foldamers are rapidly emerging as tools for protein assembly. This thesis builds on past successes with some of these scaffolds. Previously, sulfonato-calix[4]arene was ...
Chemical diversity of some benthic cyanobacteria from French Polynesia and New Caledonia
(NUI Galway, 2020-08-04)
Cyanobacteria are often considered proliferative in relation with the global change affecting oceans worldwide and especially in the coral reefs of the Pacific Ocean. The bloom of the cyanobacteria in the Pacific Ocean are ...
Characterisation of bovine pericardium and alternative treatments for its application as biomaterial
(NUI Galway, 2020-04-09)
Bovine pericardium is an extensively used biomaterial utilised in a wide range
of biomedical devices such as bioprosthetic heart valves. The characterisation
techniques employed for the analysis of bovine pericardium and ...
Towards improved performance of mediated glucose oxidising enzyme electrodes for biosensing and biopower applications
(NUI Galway, 2019-11)
Energy produced through enzymatic catalysis at electrodes, namely oxidation of glucose and
reduction of oxygen may be used to power devices. The goal of powering implantable or semiimplantable
medical devices through ...
Control of polymorphism, crystal size and habit in pharmaceuticals
(NUI Galway, 2019-09)
Crystallization is widely used as a purification method of Active Pharmaceutical Ingredients, APIs. During the process a crystalline compound is generally obtained, and it can display general properties and characteristics ...
Enhancing the bioavailability of active pharmaceutical ingredients through cocrystallization and coamorphization
(NUI Galway, 2019-12-19)
During drug research and development, improving the solubility of poorly water soluble drugs without chemically modifying the drug molecule is one of the biggest challenges for the pharmaceutical industry. Most medicines ...
Using Total Internal Reflection Fluorescence Microscopy (TIRFM) for studying protein-surface interactions
(NUI Galway, 2018-09-10)
Total internal reflection fluorescence microscopy (TIRFM) techniques play an important role in investigating phenomena which occur on transparent dielectric surfaces at nanometre scales in various research fields from ...