Now showing items 1-5 of 5
Synthesis of S-glycolipids and peptidomimetics
Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...
A study of factors influencing anomerisation reactions
This thesis involves an investigation into the anomerisation reaction and strategies by which the reaction can potentially be improved and provide a greater understanding of factors influencing the reaction. There has been ...
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)
The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ...
A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
(NUI Galway, 2018-08-08)
1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ...
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...