This thesis presents steps in the development of open-source bioelectronics that gather together and combine in the demonstration of a system capable of operating a fully integrated wireless electrochemical biosensor.

This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...

Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ...

This thesis deals with efforts to generate new bioactive organic compounds. The main focus has been on the use of carbohydrate building blocks for synthesis of both macrocyclic compounds and glycoclusters for biological ...

Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ...

The aim of this project is to synthesize and characterise novel inorganic complexes which consist of metal-based DNA cleavage entities coupled to biomolecules. It is hoped that the coupling of known DNA cleavage agents to ...

Nitric oxide (NO) is a gaseous free radical with medicinally significant properties. The NO-releasing prodrug, isosorbide-5-mononitrate (Is5N), is long established for the treatment of angina pectoris. Nitroxides are organic ...

Chapter 1 provides a literature review of metal and metal-free oxidative annulations employed to access ring-fused benzimidazoles while highlighting their significance and application towards anti-tumour benzimidazolequinones. ...

This thesis describes the isolation and identification of marine natural products from five zoantharian species collected off the Marine Protected Area El Pelado located in Santa Elena, Ecuador. Ecuador is one of the ...

Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s chemical structure and the type of immune response triggered. This thesis work has focused on the design, synthesis and ...