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Protein-carbohydrate interactions and structural characterization of Ralstonia solanacearum lectin
(2017-03-20)
Ralstonia solanacearum is a bacterium which causes fatal damage to hundreds of agricultural plants such as potato or tobacco. It produces two lectins that are involved in attachment of the bacterium to the host. One of ...
Marine biodiscovery from Floridian mangrove forests and Irish waters
(2017-08-23)
Natural products have been used since ancient times to treat illnesses and terrestrial organisms have been studied extensively from a chemical point of view. Marine organisms, on the other hand are definitely understudied ...
Integrating the old and new: smart thermoresponsive surfaces and 3D fabrication technologies for tissue engineering
(2017-05-08)
One promising direction of regenerative medicine is the development of cell sheet-based tissue-like constructs. The cell sheets preserve ECM and cell−cell junctions. This may greatly support cell adherence to damaged organ ...
Carbohydrates as precursors to macrocyclic and iminosugar frameworks
(2017-09-30)
Natural products have been perceived as privileged structures in drug discovery based on their
evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal
chemists to identify some ...
A source of new diagnostic techniques for asthma in Ireland
(2017-11-13)
The objective of this thesis is to set up new diagnostic methods for the study of asthma and related respiratory conditions in an Irish clinical laboratory, and to deepen our knowledge of the pathophysiology of this illness. ...
Combining biological and chemical approaches in marine biodiscovery
(2017-06-13)
Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical ecology, chemical ...
Studying the fluorescence emission properties of 1,2,3 triazine based fluorophores in polymer thin films
(2017-05-10)
The application of thin polymeric films for medical purposes is growing very fast.
Two of the most important uses of thin polymer films are drug coatings for controlled
release and tissue engineering. Thermoresponsive ...
Unsaturated hydrocarbon combustion chemistry and gasoline and diesel fuel ignition: Experimental and theoretical studies
(2017-12-04)
The primary objective of the work presented in this Thesis is to investigate the oxidation chemistry of unsaturated hydrocarbons. Butenes (1-, 2-, iso-butene) and 1,3-butadiene are the shortest olefins with structural ...
The use of reversible addition-fragmentation chain transfer (RAFT) polymerization, supercritical carbon dioxide and new hetero-containing monomers in polymer chemistry
(2017-08-28)
Chapter 1 is a general introduction with a description of conventional radical polymerization and reversible deactivation radical polymerizations for controlled/living techniques. In particular, the use of Reversible ...
Biofilms on electrodes and crosslinking of bovine pericardium tissue : application to biopower device development and anti-calcification of bioprosthetic valves
(2017-11-24)
Advances in the electrical communications between enzymes and electrodes made it possible to the fabrication of new miniaturized implantable power devices. This thesis is devoted to study and improvement of enzyme electrodes ...