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Investigating the epigenetic regulation of toll-like receptor 3
Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ...
Inflammatory-environment interactions as an approach to modelling Parkinson's disease
It has been over 50 years since the first demonstration that levodopa was capable of reversing the motor dysfunction associated with Parkinson’s disease. In the intervening decades, although levodopa has remained the most ...
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ...