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Urothelial carcinoma: Molecular profiling and potential application in clinical practice
(NUI Galway, 2020-02-19)
Urothelial Carcinoma: Molecular Profiling & Potential Application in Clinical Practice
Abstract
Introduction: Urothelial carcinoma is characterised by a tendency to recurrence and risk of progression that necessitates ...
The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism
(NUI Galway, 2020-10-20)
Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ...
Ablation of FAP+ stromal cells impairs endogenous revascularization during hind limb ischemia
(NUI Galway, 2020-05-08)
Stromal cells have long been studied for their putative role in maintaining tissue homeostasis,
driving tissue remodeling processes during injury, and modulating inflammation by
synergizing with immune cells. Studying ...
Processing the scientific literature for protein relations (for myocardial infarction) and validation of hypothetical relations through experimental results
(NUI Galway, 2020-02-28)
The last decade has been characterized by a deluge of published scientific literature as well as data generation by biological experiments. The major impediment for the research community to unlock the knowledge contained ...
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)
Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the
tumour and bypass the host immune system. Extracellular Vesicles (EVs) are
thought to be a fingerprint of the parent cell and therefore MSC-EVs ...
Diagnostic insights from twenty years of bilateral inferior petrosal sinus sampling for Cushings Disease at Mayo Clinic (1998-2018)
(NUI Galway, 2020-03-02)
Pituitary-dependent Cushing syndrome (CS), referred to herein as Cushing Disease (CD), is the most common cause of endogenous CS. The challenge for diagnosing CD includes difficulty identifying the often small pituitary ...
The role of the aquatic environment in the spread of antimicrobial resistance of public health significance
(NUI Galway, 2020-02-27)
Antimicrobial resistance (AMR) is one of the greatest threats to human health of the 21st Century, with certain antimicrobial resistant organisms classified as being a greater threat to public health than others. At the ...
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)
Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ...
Feasibility of mesenchmyal stem cells as modulators of inflammation and as a cellular model to study cartilage damage in osteoarthritis
(NUI Galway, 2020-04-10)
Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ...
Changes in anthropometric and metabolic outcomes during and after a milk-based meal replacement programme in bariatric patients
(NUI Galway, 2020-04-14)
During this work, I examined a cohort of patients with severe and complicated obesity undergoing a milk-based intensive weight management programme, examining changes in various traits in the short and medium term.
Firstly, ...