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Macromolecular crowding for chondrogenic phenotype maintenance and stem cell differentiation
(NUI Galway, 2019-01-31)
Chondrocyte-based tissue engineering therapies require in vitro cell expansion, which is associated with loss of phenotype, decrease in synthesis of collagen type II and increase in synthesis of collagen type I. Another ...
Elastin-like recombinamers-based hydrogel modulates the post-ischemic remodelling in a clinically-relevant model of myocardial infarction
(NUI Galway, 2019-04-17)
Myocardial infarction (MI) belongs to the family of cardiovascular diseases and represents the primary cause of worldwide mortality. Despite the promising results achieved in both small and large animal studies, recent ...
Computational modelling of the coupled electro-mechanical behaviour of neurons
(NUI Galway, 2019-01-22)
Recent experimental evidence has uncovered complex biophysical phenomena accompanying the electrical activity of nervous cells. Now emerging theories refer to the electric pulse, i.e. the Action Potential (AP), as an ...
Development and characterisation of compressed, macro-porous and collagen-coated poly-ε-caprolactone electrospun meshes
(NUI Galway, 2019-02-25)
Electrospun scaffolds are utilised in a diverse spectrum of clinical targets, with an ever-increasing quantity of work progressing to clinical studies and commercialisation. However, the very dense architecture and the low ...
Elastin-based hydrogel as a treatment for critical limb ischemia, an insight into the glyco-host response
(NUI Galway, 2019-10-01)
Critical limb ischemia (CLI) is severe impairment of the microcirculation resulting in inflammation, ischaemic pain, non-healing ulcers and gangrene. Over 20% of patients have no option but to undergo a major limb amputation. ...
Mechanobiological changes during estrogen deficiency leading to bone loss
(NUI Galway, 2019-12-18)
Osteoporosis, which predominantly occurs in females, affects 200 million women worldwide and is characterised by bone loss and microarchitectural degradation, which leads to fractures, pain and immobility. Conventional ...
Fibrin-in-fibrin intervention for enhanced dopaminergic graft survival in Parkinson’s disease: Special focus on brain N-glycans
(NUI Galway, 2019-11-07)
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder caused due to the selective loss of dopaminergic neurons in substantia nigra pars compacta (SN) translating into the classical motor symptoms ...
Biophysical and biochemical microenvironmental cues for tenogenic phenotype maintenance, differentiation and trans-differentiation in vitro
(NUI Galway, 2019-07-19)
Tendon injuries affect tens of millions of people worldwide each year and as the average lifespan increases their occurrence also increases, Achilles rupture rates alone have increased by ≈ 1000% in the last 40 years. ...