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Interferon alpha-induced changes in emotional and nociceptive processing: involvement of the endocannabinoid system
Interferon-α (IFN-α) is a pro-inflammatory cytokine used for the treatment of hepatitis B and C as well as various malignancies. However, therapy is often associated with neuropsychiatric side effects, including depression ...
The role of the endocannabinoid system in the affective modulation of pain
Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ...