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Molecular investigation into the roles of Sigma B and the Stressosome in the response of Listeria monocytogenes to environmental stress
(NUI Galway, 2019-07-15)
The alternative sigma factor, SigB, has been studied extensively in Listeria monocytogenes, Bacillus subtilis and Staphylococcus aureus, and is known to regulate the general stress response in these bacteria. The activation ...
Predation, competition and conservation: An investigation of the behavioural ecology of the internationally-protected Geomalacus maculosus
(NUI Galway, 2019-02-14)
The Kerry spotted slug Geomalacus maculosus is protected internationally on the basis of its limited global distribution in that it occurs only in the west of Ireland and north-western Iberia. Spanish populations are listed ...
A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
(NUI Galway, 2019-04-23)
Reproducing the systems biology efforts established across areas of cell biology such as integrating biological networks with omic datasets and subjecting it to modelling analysis for studying the functional involvement ...
Novel multiplex isothermal nucleic acid amplification technologies for the detection of bacterial meningitis associated pathogens
(NUI Galway, 2019-02-28)
Infectious diseases, caused by pathogenic microorganisms such as bacteria, fungi or viruses, are a leading cause of significant global morbidity and mortality, with over 10 million associated deaths reported each year. ...
Characterisation of histone variants in the cnidarian Hydractinia
(NUI Galway, 2019-02-21)
Hydractinia is a marine hydrozoan cnidarian that has been a model organism for developmental biology for over a century. Very few studies have been carried out on chromatin biology in cnidarians. To date, there is no ...
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)
The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ...
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)
Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ...
Effects of exogenous B-cell immunoglobulin binding protein (BIP) and BIP protein inducer X (BIX) on myelination
(NUI Galway, 2019-12-12)
B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone that belongs to the Hsp70 family, normally found in the ER lumen. However, BiP also has other extracellular and intracellular ...
Marine and freshwater influences on the hydrography, oxygen dynamics and ecology of an anoxic lagoonal estuary, Lough Furnace, Mayo, Ireland
(NUI Galway, 2019-10-08)
Estuarine and coastal water bodies are amongst the most productive and diverse habitats, providing crucial ecological and economic benefits. However, owing to their position at the interface between continents and the ...
A study of the presentation and biological effects of biofilm component poly-N-acetylglucosamine from Staphylococcus aureus and Acinetobacter baumannii using novel multidisciplinary platforms and methods
(NUI Galway, 2019-09-24)
Biofilm formation on medical devices is major cause of concern in today’s society as implanted devices are associated with 60-70% of nosocomial infections. Poly-N-acetylglucosamine (PNAG) is a polysaccharide found on many ...