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Molecular investigation into the roles of Sigma B and the Stressosome in the response of Listeria monocytogenes to environmental stress
(NUI Galway, 2019-07-15)
The alternative sigma factor, SigB, has been studied extensively in Listeria monocytogenes, Bacillus subtilis and Staphylococcus aureus, and is known to regulate the general stress response in these bacteria. The activation ...
A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
(NUI Galway, 2019-04-23)
Reproducing the systems biology efforts established across areas of cell biology such as integrating biological networks with omic datasets and subjecting it to modelling analysis for studying the functional involvement ...
Characterisation of human nucleolar organisers located in previously uncharted regions of the human genome
(NUI Galway, 2019-01-18)
The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis.
Nucleoli form around chromosomal loci called ‘nucleolar organiser regions (NORs)
located on the short arms of the human acrocentric ...
Characterisation of histone variants in the cnidarian Hydractinia
(NUI Galway, 2019-02-21)
Hydractinia is a marine hydrozoan cnidarian that has been a model organism for developmental biology for over a century. Very few studies have been carried out on chromatin biology in cnidarians. To date, there is no ...
Investigations of spicules and spicule formation in Haplosclerida (Porifera, Demospongiae) using a multidisciplinary approach
(NUI Galway, 2019-01-09)
Sponges are simple animals and their body is formed by different cell types and a dense skeleton either of collagen, chitin or spicules made of amorphous silica or calcium carbonate that they secrete. The phylum Porifera ...
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)
Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ...
Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
(NUI Galway, 2019-10-25)
Acute myeloid leukaemia (AML) is a malignancy caused by a block in differentiation in which
aberrant leukemic stem cells drive the production of undifferentiated or partially differentiated
leukemic blast cell clones. ...
Impact of light intensities and low temperature on the composition and diurnal use of transient carbon stores in barley (Hordeum vulgare)
(NUI Galway, 2019-10-18)
The carbon partitioning and accumulation are critical for biomass formation in
plants and can be affected by environmental changes and regulated by circadian clock.
Thus, in this study, barley was grown under three light ...
Reverse genetic analysis of centrosomal roles of Checkpoint Kinase 1
(NUI Galway, 2019-06-14)
Centrosome duplication is tightly regulated process that occurs only once per cell cycle. Centrosome abnormalities have been observed in cancer cells and in cells with defective DNA damage responses. Genotoxic stresses ...
Novel multiplex isothermal nucleic acid amplification technologies for the detection of bacterial meningitis associated pathogens
(NUI Galway, 2019-02-28)
Infectious diseases, caused by pathogenic microorganisms such as bacteria, fungi or viruses, are a leading cause of significant global morbidity and mortality, with over 10 million associated deaths reported each year. ...