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Development of novel nucleic acid diagnostics technologies for the detection of predominant microorganisms associated with bacterial meningitis
(2017-01-13)
With an estimated 1.2 million cases annually worldwide, bacterial meningitis is a
medical emergency and primary prevention as well as accurate diagnosis and
treatment of this often fatal disease is paramount. The ...
Molecular microbial ecology of ammonia oxidation in coastal sediments
(2017-02-10)
This thesis focuses on the processes of nitrification in three coastal bays, specifically, aerobic ammonia oxidation which is the rate limiting step of nitrification and is mediated by ammonia oxidising bacteria and/or ...
Exploiting homogeneous oxacillin resistance in methicillin resistant staphylococcus aureus to Identify novel anti-virulence therapeutic targets
(2017-06-08)
The number of antibiotic-resistant bacterial infections have continued to increase in recent
years and have drawn global concern to the potential future of living in a post-antibiotic
era. These infections are of major ...
Understanding the role of the general stress response regulator, RpoS, in the environmental persistence of Escherichia coli
(2017-04-03)
The use of E. coli as an indicator organism for faecal contamination in the environment, particularly in water sources, is based partly on the assumption that E. coli survives transiently outside of the mammalian ...
Characterization of a novel antimicrobial agent inspired by peroxidase-catalyzed systems
(2017-09-29)
The phenomenon of antibiotic resistance is expanding and the threat regarding our future ability to combat infection is increasing. Thus, key challenges for society and for researchers are to address microbial drug resistance ...
Pure culture, co-culture and whole ecosystem investigations of single anaerobes, partnerships and microbial communities in anaerobic digestion
(2017-10-20)
Anaerobic digestion (AD) is a multi-stage process whereby biodegradable material is broken down by complex microbial consortia into renewable CH4 in the absence of oxygen during waste and wastewater treatment. Anaerobic ...
Investigations into soil microbiome stability in the face of agriculture and climate change related perturbations
(NUI Galway, 2017-11-05)
Soils and the vital ecosystem services performed by their indigenous microbiota are under increasing pressure from anthropogenic stresses and climate change. In an effort to understand how the provision of soil ecosystem ...
The X Factor(s): New antibiotic resistance mechanisms in community-associated methicillin resistant Staphylococcus aureus
(2017-03-31)
Methicillin-resistant Staphylococcus aureus (MRSA) strains typically express low-level heterogeneous (HeR) resistance from which high-level homogeneously resistant (HoR) mutants can be isolated following oxacillin exposure. ...
Identification and characterisation of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
(2017-03-24)
Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ...