Search
Now showing items 1-10 of 21
Development of a microgel-based cell delivery platform for critical limb ischemia
(2017-05-05)
Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ...
Modulation of inflammatory pain in intervertebral disc degeneration: A therapeutic biomaterials approach
(2017-10-05)
Discogenic low back pain (LBP) is a very common health problem that imposes a socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the causative factors of LBP. It is mediated by an ...
The importance of a continuum of care before, during and after pregnancy in women with type 1 and type 2 diabetes along the Irish Atlantic seaboard
(2017-04-06)
Pregestational diabetes is the most common chronic medical condition to complicate pregnancy and is associated with an increased risk of morbidity and mortality for the mother-offspring pair. Optimising outcomes for this ...
Inflammatory-environment interactions as an approach to modelling Parkinson's disease
(2017-09-22)
It has been over 50 years since the first demonstration that levodopa was capable of reversing the motor dysfunction associated with Parkinson’s disease. In the intervening decades, although levodopa has remained the most ...
Genetically modified mesenchymal stem cells overexpressing CCR2 for cell therapy in critical limb ischemia
(2017-09-21)
Critical Limb Ischemia (CLI) is an advanced stage of Peripheral Arterial Disease (PAD) and a global health problem. Patients with CLI may present with rest pain, gangrene and/or ulceration of the lower limb. Effective ...
Quality of life in psychotic illness: baseline and prospective determinants in first episode and chronic psychosis cohorts
(2017-08-01)
Abstract
The overall aim of this thesis was to longitudinally assess determinants of quality of life in first episode and chronic psychosis patient cohorts.
The Galway First Episode Psychosis Cohort
Background:
In ...
Endocannabinoid modulation of TLR3-induced neuroinflammation
(2017-10-06)
Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ...
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)
Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ...
Characterisation of triple negative breast carcinoma and identification of the value of immunohistochemical markers and stromal tumour infiltrating lymphocytes
(NUI Galway, 2017-10)
Breast cancer is a complex disease that encompasses multiple molecular subtypes that have different clinical behavior. The behavior can be influenced by both the characteristics of the cancer cells as well as the surrounding ...
Multiple myeloma: The role of glycosylation in disease development and progression.
(2017-09-09)
Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by skeletal destruction, renal failure, anaemia and hypercalcaemia. MM cells are intimately associated with the bone marrow microenvironment, ...