Double stranded DNA encodes the genetic material of the cell. Replication and segregation cycles are regulated in order to maintain the integrity of the DNA sequence from one cell cycle to the next. Detection of lesions ...

Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ...

Hydractinia is a colony forming marine invertebrate and a member of the phylum Cnidaria. Members of this genus have been models for developmental biologists for over a century and feature many characters of evolutionary ...

Triple negative breast cancers (TNBC) lack estrogen and progesterone receptors, and HER-2 markers rendering them resistant to current targeted therapies. Most TNBCs show basal-like characteristics and the terms TNBC and ...

This thesis sets out to explore the potential bioactivities of bovine milk fat globule membrane (MFGM) to enhance our understanding of the roles bovine milk glycoconjugates may play in humans and to contribute towards ...

To protect the DNA against the constant assaults of endogenous and environmental agents, cells have developed conserved signaling pathways, known as the DNA damage response. Such responses are important to maintain genome ...

Neurotrophins are important growth factors for neuronal cells. They interact with the Trk kinase receptors and the p75NTR receptor to induce several signaling pathways. Neurotrophins and their receptors are known regulators ...

Triple negative breast cancers (TNBC) lack estrogen, progesterone and HER-2 receptors rendering them insensitive to current hormone targeted therapies. However, TNBC have been reported to express and secrete an additional ...

CDC7 is an essential serine/threonine kinase required for the initiation of DNA replication in eukaryotic cells, through phosphorylating the MCM helicase complex. Formation of an active kinase requires the binding to ...

The centromere is a genetic locus present once per chromosome that specifies the site of kinetochore formation and is vital for chromosomal segregation. With the exception of Saccharomyces cerevisiae, whose ‘point’ ...