Now showing items 1-6 of 6
Synthesis and application of chiral substituted oxazolines
This thesis consists of two subprojects, dealing with the design, synthesis and application of novel (1) pyridinyl-oxazoline ligands and (2) prolyl-oxazoline ligands. In Project 1 eleven novel pyridinyl-oxazoline ligands ...
Design, synthesis and catalytic activity of novel oxazoline based ligands
This thesis can be viewed as two separate studies. Firstly, the design, synthesis and catalytic activity of novel 2-pyridyl mono(oxazoline). A family of mono(oxazoline) ligands were developed in which the 5-poition is ...
The anomerisation of glycosyl thiols and synthesis of multivalent GlcNAc and GalNAc glycoclusters
There are several published procedures available for the synthesis of b-thiopyranoses such as gluco- or galacto-pyranoses. Given the ease with which one can access such b -thiopyranoses, the development of a reproducible ...
Synthesis and investigation of artificial metallonucleases
The aim of this work is the synthesis and investigation of artificial metallonucleases. In the first part of this work a simple model system was used allowing for the quantification of the artificial nucleases ability. ...
Synthetic investigations into discrete polynuclear cage formation and their subsequent incorporation into extended network materials
This thesis details the synthesis and structural characterisation of thirty novel complexes via the utilisation of a variety of ligands (seven in total) including hydroxamic acids, Schiff base ligands and their hybrid ...
Computational design of glycomimetic inhibitors of Influenza A Adhesion
Many pathogens, such as avian influenza, Helicobacter pylori and Streptococcus pneumoniae, employ cell-surface glycans which terminate in Neu5AcAlpha(2-3)Gal as their adhesion partner. As a result, a glycomimetic ...