Search
Now showing items 1-6 of 6
Computational design of glycomimetic inhibitors of Influenza A Adhesion
(2015-02-16)
Many pathogens, such as avian influenza, Helicobacter pylori and Streptococcus pneumoniae, employ cell-surface glycans which terminate in Neu5AcAlpha(2-3)Gal as their adhesion partner.[1] As a result, a glycomimetic ...
Synthesis and application of chiral substituted oxazolines
(2015-09-08)
This thesis consists of two subprojects, dealing with the design, synthesis and application of novel (1) pyridinyl-oxazoline ligands and (2) prolyl-oxazoline ligands.
In Project 1 eleven novel pyridinyl-oxazoline ligands ...
The anomerisation of glycosyl thiols and synthesis of multivalent GlcNAc and GalNAc glycoclusters
(2015-04-29)
There are several published procedures available for the synthesis of b-thiopyranoses such as gluco- or galacto-pyranoses. Given the ease with which one can access such b -thiopyranoses, the development of a reproducible ...
Synthesis and investigation of artificial metallonucleases
(2015-04-29)
The aim of this work is the synthesis and investigation of artificial metallonucleases.
In the first part of this work a simple model system was used allowing for the
quantification of the artificial nucleases ability. ...
Design, synthesis and catalytic activity of novel oxazoline based ligands
(2015-08-14)
This thesis can be viewed as two separate studies. Firstly, the design, synthesis and catalytic activity of novel 2-pyridyl mono(oxazoline). A family of mono(oxazoline) ligands were developed in which the 5-poition is ...
Synthetic investigations into discrete polynuclear cage formation and their subsequent incorporation into extended network materials
(2015-01-20)
This thesis details the synthesis and structural characterisation of thirty novel complexes via the utilisation of a variety of ligands (seven in total) including hydroxamic acids, Schiff base ligands and their hybrid ...