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Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)
Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ...
Invasive haemodynamic characteristics and clinical outcomes of patients presenting with symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation
(2016-01-12)
The present thesis is comprised of an introduction followed by eight chapters. The introduction gives an overview of the transcatheter aortic valve implantation (TAVI) procedure and details the patient selection process. ...
Exosomal microRNAs in colorectal cancer
(2016)
Cancer cells have been shown to release a variety of extracellular membrane vesicles
including microvesicles known as exosomes. Exosomes have recently been found to
contain microRNAs (miRNAs) however the full range within ...
Phenotypic and functional heterogeneity of intermediate monocytes in healthy adults.
(2015-09-30)
Human blood monocytes are currently classified into three subsets: CD14++CD16- “Classical”, CD14++CD16+ “Intermediate” and CD14+CD16++ “Non-Classical”. Distinct functional differences between Classical and Non-Classical ...
Investigating the role of the endogenous cannabinoid system in emotional modulation of pain: neurochemical and molecular mechanisms
(2012-03-24)
Abstract
Pain represents a major unmet clinical need and affects a large number of individuals worldwide. The modulation of pain by cognitive and emotional factors is now widely recognised. Increased understanding of the ...
Medical student selection: a mixed methods study
(2015-09-29)
Selection to medicine is widely considered the single most important assessment of a doctor's medical career. It is a key deciding factor in the composition of the medical workforce. Selectors have a social responsibility ...
Allogeneic cell therapy for osteoarthritis
(2016-05-11)
Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ...
The role of glycosylation in regulatory T-cell biology
(2016-12-14)
Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. There has been a significant amount of research devoted to understanding their physiological mechanisms of action and the ...
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
(2015-11-05)
Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ...
Topics in cocyclic development of pairwise combinatorial designs
(2015-10-14)
This thesis is a compilation of results dealing with cocyclic development of pairwise combinatorial designs. Motivated by a classification of the indexing and extension groups of the Paley Hadamard matrices due to de ...