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Now showing items 81-90 of 118
Using Total Internal Reflection Fluorescence Microscopy (TIRFM) for studying protein-surface interactions
(NUI Galway, 2018-09-10)
Total internal reflection fluorescence microscopy (TIRFM) techniques play an important role in investigating phenomena which occur on transparent dielectric surfaces at nanometre scales in various research fields from ...
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Theoretical, experimental and modelling studies of the reactions of hydrogen atoms with C2 – C5 alkenes and cyclisation reactions of hydroperoxyl-alkyl radicals forming cyclic ethers and hydroxyl radicals
(NUI Galway, 2021-06-22)
This thesis presents a hierarchical study of the reactions of Ḣ atom addition to and abstraction from both linear and branched C2 – C5 alkenes. The subsequent C–C and C–H β-scission reactions and H-atom transfer reactions ...
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)
The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in
carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers
a facile method to generate 1,2-cis ...
A theoretical and kinetic modelling study of free radical addition reactions to unsaturated C2, C3 and C5 hydrocarbons
(NUI Galway, 2021-02-02)
Radical addition to the double bond of an olefin is an important reaction class in combustion mechanism development. Addition reactions of free radicals to small alkenes (C2 – C3) have been studied here at high levels of ...
Study of protein-polymer nanoparticle interactions using advanced fluorescence-based approaches: Fluorescence fluctuation spectroscopy
(NUI Galway, 2020-09-30)
Biologics are a class of drug products that are produced in part or in its totality from living organisms, one of the main examples of which are therapeutic proteins. During the production, processing, and purification ...
The study of protein chemical modification using polarized Excitation Emission Matrix (pEEM)
(NUI Galway, 2020-11-30)
The advances in drug development and the increased use of biologics as therapeutics drives the need for more effective Process Analytical Technology (PAT) tools to measure biophysical changes during manufacturing and ...
A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
(NUI Galway, 2018-08-08)
1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ...
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)
This thesis deals with efforts to generate new bioactive organic compounds. The main focus
has been on the use of carbohydrate building blocks for synthesis of both macrocyclic
compounds and glycoclusters for biological ...
Synthesis and characterization of new metal-organic frameworks by the use of 2-Pyridyl oximes or alcohols in combination with poly-carboxylic ligands
(NUI Galway, 2022-01-27)
The aim of this project is the synthesis and characterization of novel mixed-ligand coordination polymers and metal-organic frameworks (MOFs) and their further study as magnetic sensors for the adsorption of non-environmental ...