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Now showing items 71-80 of 118
Control of polymorphism, crystal size and habit in pharmaceuticals
(NUI Galway, 2019-09)
Crystallization is widely used as a purification method of Active Pharmaceutical Ingredients, APIs. During the process a crystalline compound is generally obtained, and it can display general properties and characteristics ...
Enhancing the bioavailability of active pharmaceutical ingredients through cocrystallization and coamorphization
(NUI Galway, 2019-12-19)
During drug research and development, improving the solubility of poorly water soluble drugs without chemically modifying the drug molecule is one of the biggest challenges for the pharmaceutical industry. Most medicines ...
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) as a tool for biophysical analysis
(NUI Galway, 2021-10)
The development of analytical tools for the biophysical analysis of biological
samples is an area of tremendous application and potential. In this work the use and
efficacy of an analytical methodology, known as anisotropy ...
Advances in ruthenium-based light harvesting materials and photocatalysis: From molecular photosensitizers to photoactive frameworks
(NUI Galway, 2022-04-08)
The presented manuscript deals with the areas of light harvesting and photocatalysis in solar chemistry. The work presented is divided into several sections, beginning with an introductory chapter on the main topics involved ...
Carbohydrates as precursors to macrocyclic and iminosugar frameworks
(2017-09-30)
Natural products have been perceived as privileged structures in drug discovery based on their
evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal
chemists to identify some ...
Crystal Growth Using Low Temperature Gradient Sublimation in Vacuo
(2012-09-27)
A sublimation method based on the use of a conventional vacuum oven was developed for growing high quality single crystals of organic compounds suitable for structure determination. Key features of the method are the use ...
Crystal growth and design of multicomponent pharmaceuticals
(NUI Galway, 2022-08-30)
Cocrystallisation and salt formation is a widely studied method of optimising the action of
Active Pharmaceutical Ingredients (APIs) without chemical modification of the parent
compound. Careful selection of suitable ...
Irelands’ hidden pharmacy: Marine biodiscovery applied to deep-sea sponges and corals
(NUI Galway, 2022-06-08)
Natural products have provided over 60% of our medicines to date, but their search has focused on easy to access habitats, leaving the marine realm underexplored. The deep-sea, which is the world’s largest biome and ...
Small–molecule reagents and building–blocks for protein materials and bioconjugation
(NUI Galway, 2023-04-18)
The molecular and functional diversification conferred by posttranslational modification
(PTM) of proteins is a common target and source of inspiration for chemical biologists.
For example, the formylglycine-generating ...
Mediated glucose biosensors for application in continuous glucose monitoring
(NUI Galway, 2023-04-19)
Diabetes affects 1 in 11 people globally and requires monitoring of blood glucose
levels as a part of its treatment. Initial blood glucose monitoring devices involved
finger prick testing at regular intervals daily, a ...