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Now showing items 51-60 of 137
Optimising the maturation rate of arteriovenous fistula (AVF) in patients with end stage renal disease (ESRD)
(2016-01-25)
A well-functioning Arteriovenous Fistula (AVF) has been shown to be the best modality for access in patients with end-stage kidney disease going for dialysis. Maturation of AVF is complex and depends on various biomechanical ...
Social and clinical features of HIV infection in older children and adolescents in Zimbabwe
(2017-09-29)
Introduction
HIV infection has had a devastating effect on morbidity and mortality of children and adolescents, particularly in low- income settings. Zimbabwe has been at the epicentre of the HIV epidemic since mid-1990. ...
Role of MicroRNAs and unfolded protein response in breast cancer
(2017-11-24)
Stressful conditions of the tumour microenvironment which overwhelm the folding capacity of the endoplasmic reticulum (EnR) activate an evolutionary conserved signalling pathway known as the unfolded protein response (UPR). ...
Evaluation of the efficacy of the Baska Mask
(NUI Galway, 2018-03-22)
The Baska mask is a new supraglottic airway device (SAD). Its novel features include a non-inflatable cuff consisting of a silicone membrane, and an oesophageal drainage system with sump reservoir, connected to 2 drainage ...
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
(2016-06-15)
Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ...
Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer
(2016-11-30)
Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ...
MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)
Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ...
Investigating the role of the endogenous cannabinoid system in emotional modulation of pain: neurochemical and molecular mechanisms
(2012-03-24)
Abstract
Pain represents a major unmet clinical need and affects a large number of individuals worldwide. The modulation of pain by cognitive and emotional factors is now widely recognised. Increased understanding of the ...
Medical student selection: a mixed methods study
(2015-09-29)
Selection to medicine is widely considered the single most important assessment of a doctor's medical career. It is a key deciding factor in the composition of the medical workforce. Selectors have a social responsibility ...
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)
Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ...