Search
Now showing items 51-60 of 85
Pulsatile Drug Delivery by Thermoresponsive Polymer Films with Mathematical Model and Evaluation of Thermoresponsive Properties of Block Copolymers
(2012-11-26)
In this thesis, a new controlled thermoresponsive drug delivery system based
on UV crosslinkable copolymer films was fabricated and characterised. The
characterisation of the drug loaded films has shown an even drug ...
N- and O- linked Glycosylation, Developing Mass Spectrometric Strategies for the Characterisation of Glyco-epitopes
(2012-12-10)
The overall goal of this thesis was to adopt a liquid chromatography-mass spectrometry (LC-MS) platform for glycomic analysis of glycoproteins. In particular we were interested in characterizing complex glycomic samples ...
Bioelectrochemical films on electrodes for application to biofuel cells
(2012-05-04)
This thesis focuses on studies of both enzymatic (EFC) and microbial (MFC) fuel cells. In the enzymatic fuel cell studies, interactions between enzymes, osmium based complexes and redox polymers are characterized ...
The use of Acetic Anhydride in Annulations onto Benzimidazoles to give Novel Reducible p-Dione Adducts
(2012-06-13)
Chapter 1: Introduction to the reactive intermediates used in this thesis, namely acyl radicals and N-heterocyclic carbenes (NHC) is presented, along with an assessment of the anti-cancer activity of literature bioreductive ...
Computational Studies of Hypericin and Porphyrin Derivatives for Photodynamic Therapy - Spectra, Membrane Simulations, and Protein Interactions
(2011-08)
Photosensitizing compounds with potential application in anticancer treatment with photodynamic therapy were investigated by means of computational methods in the studies presented in this thesis.
Hypericin and brominated ...
Green solvent free methods for active pharmaceutical ingredient polymorph control
(NUI Galway, 2018-09-28)
Polymorphism control of pharmaceutical compounds is a fundamental issue in pharmaceutical companies. Solution crystallization is a well-known pharmaceutical process. There are a variety of factors that can influence the ...
Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide
(NUI Galway, 2018-10-15)
Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these ...
Combustion kinetic studies of future transportation fuels and intermediates
(NUI Galway, 2020-10-22)
The transportation sector requires an abundant supply of fossil and/or bio-derived fuels,
which all produce significant quantities of greenhouse gas (GHG) emissions. The
transportation sector is expected to account for ...
Chemical diversity of zoantharians from the coast of Ecuador in the tropical eastern Pacific
(NUI Galway, 2019-09-18)
This thesis describes the isolation and identification of marine natural products from five zoantharian species collected off the Marine Protected Area El Pelado located in Santa Elena, Ecuador. Ecuador is one of the ...
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)
Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ...