The purpose of this study was to explore autonomy for older people in residential care. A single exploratory embedded case study design was used. The case study was adopted for the purpose of gaining a better understanding ...

Within Europe, montane oceanic vegetation is restricted to areas with an oceanic climate, such as western Ireland. It was found that a wide range of montane heath and associated vegetation occurs in western Ireland, and ...

Despite many technological advances, the information overload problem still prevails in many application areas. It is challenging for users who are inundated with data to explore different facets of a complex information ...

Ataxia-telangiectasia (A-T) is a rare human disease characterized by cerebellar degeneration, immune system defects and cancer predisposition. The disease has been the subject of intense scientific scrutiny, particularly ...

The overall goal of this thesis was to adopt a liquid chromatography-mass spectrometry (LC-MS) platform for glycomic analysis of glycoproteins. In particular we were interested in characterizing complex glycomic samples ...

The mechanisms of lineage commitment and acquiring specific cell fate remain obscure and require investigating the role of particular genes involved in these complex processes. To address this issue, I studied the role of ...

This thesis describes the synthesis and application of four novel chiral ligand classes. These were all hydroxyamide or oxazoline ligands with an L-pyroglutamic acid derived terminus. These ligands ...

Depression during pregnancy and the postpartum period has been associated with deleterious consequences such as preterm birth, low birth weight and less optimal scores on neonatal reflexes and behaviour. Pharmacological ...

Functional ability describes a person's capability to perform those tasks that are necessary to live independently. It is a proven predictor of functional decline, the need for hospitalisation and institutionalisation ...

The biomechanisms which govern the response of chondrocytes to mechanical stimuli are poorly understood. This thesis aims to provide a more in depth understanding of chondrocyte biomechanics by focusing on the role of actin ...