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Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)
Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ...
Therapies for acute respiratory distress syndrome: determination of the mechanisms of action of hypercapnia and the therapeutic efficacy of mesenchymal stromal cells
(2016-09-20)
Rationale: Acute Respiratory Distress Syndrome (ARDS) causes severe respiratory failure and is associated with high mortality. Pharmacological therapies are non-existent and supportive ventilation treatments are limited. ...
Investigating the epigenetic regulation of toll-like receptor 3
(2017-10-20)
Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ...
The need for and effectiveness of an individualised therapeutic programme for people living with prolonged disorders of consciousness in non-specialist care settings in the Republic of Ireland
(2016-11-16)
Introduction: Disorders of consciousness are an increasing phenomena and people are living longer with these conditions. The care needs begin with acute medicine and ICU care and frequently end up with life-long nursing ...
microRNA-mediated intercellular communication in the primary breast tumour microenvironment
(2014-08-30)
microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ...
Atrial fibrillation and stroke: natural history, risk factors and clinical consequences
(2013-08-28)
Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor for ischaemic stroke, associated with a five-fold increase in risk. ...
The importance of a continuum of care before, during and after pregnancy in women with type 1 and type 2 diabetes along the Irish Atlantic seaboard
(2017-04-06)
Pregestational diabetes is the most common chronic medical condition to complicate pregnancy and is associated with an increased risk of morbidity and mortality for the mother-offspring pair. Optimising outcomes for this ...
Inflammatory-environment interactions as an approach to modelling Parkinson's disease
(2017-09-22)
It has been over 50 years since the first demonstration that levodopa was capable of reversing the motor dysfunction associated with Parkinson’s disease. In the intervening decades, although levodopa has remained the most ...
Health literacy levels in women at risk of gestational diabetes mellitus attending antenatal services in University Hospital Galway
(2017-05-10)
Introduction
The 2011 population study on health literacy found that 40% of the Irish population had inadequate health literacy. There has been little research in Ireland and internationally on health literacy in pregnancy. ...
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
(NUI Galway, 2018-04-06)
Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ...