microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ...

Skeletal muscle is a major tissue type in humans, comprising approximately 40% of total body mass in adults. Skeletal muscle is ultimately composed of elongated multinucleate cells known as myofibers. These myofibers are ...

Introduction: Involuntary admission is often a traumatic experience for patients and it is associated with negative attitudes which can persist after the episode of illness has abated. Aims: The aims of the study were ...

Abstract The overall aim of this thesis was to longitudinally assess determinants of quality of life in first episode and chronic psychosis patient cohorts. The Galway First Episode Psychosis Cohort Background: In ...

The amount of biomedical data produced by DNA-sequencing, by curated knowledge on disease mechanisms and treatments, by results from biochemical and pharmaceutical research and by many other data generation studies is ...

Mesenchymal stromal cell (MSC) therapies are being successfully developed for immune-mediated inflammatory diseases as phase 3 clinical trials have demonstrated. However, the en-dogenous roles of stromal cells (SSCs) are ...

Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ...

Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ...

Diabetic ulcer healing is a major problem in health care. Impaired circulation has long been associated with diabetes resulting in an increased risk of foot ulceration and making an increase in blood flow an excellent ...

Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ...