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Now showing items 31-40 of 187
Investigation of intron coevolution and the autoimmune potential of alternative splicing
(2016-07-20)
Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ...
The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
(2016-07-08)
Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ...
Modelling, planning and adaptive implementation of semantic event service
(2016-05-13)
Recent developments in sensor networks, social media, process management and data analysis envisions interlinked devices, people, processes and data, constituting an Internet-of-Everything. These networks can be used to ...
Developing and characterizing cellular models for neurodegenerative diseases.
(2016-05-13)
The focus of this work was to develop and validate in vitro cell culture models of neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease characterized ...
Mindfulness and critical thinking: structural relations, short-term state effects, and long-term intervention effects
(2016-12-14)
Background -
In recent years, many claims have been made regarding the application of mindfulness practice to the improvement of everyday thinking skills. Everyday thinking skills are best measured using assessments ...
Biological characterization of a human mesenchymal stromal cell product
(2016-07-21)
The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ...
Assessment of environmental compliance of waterbodies through integration of monitoring and modelling
(2016-09-30)
Design of water quality monitoring networks in estuarine and coastal waters is hampered by a lack of a clear methodology. Monitoring networks are designed on an ad-hoc basis supported by experts in the area. Guidance on ...
Reverse genetic analysis of Cep164 in vertebrates
(2016-05-12)
Components of the centrosome have been reported to have a role in the DNA Damage Response (DDR) pathway. Cep164, a protein localised to the distal appendages of centrioles, is theorised to play a part in the DDR. As with ...
Equality omitted reform: an exploration of 'egalitarian' and 'efficiency' principles in Irish health care provision within an institutionalist framework.
(2016-05-11)
This thesis is an exploratory study of the theory and practice of equality in shaping modern policy conceptions of access and entitlement to health care provision. In most modern democratic societies, the principles of ...
Involving children and young people in social research: navigating the balance between protection and participation
(2016-10-14)
This thesis is an article-based PhD. Against the backdrop of the almost universal acceptance of the UN Convention on the Rights of the Child and the scholarly works comprising the ‘new social studies of childhood’, the ...