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Now showing items 21-30 of 137
Pro-inflammatory cytokine licensing as a strategy to enhance the efficacy of syngeneic mesenchymal stem cells for corneal transplantation
(NUI Galway, 2018-05-11)
It has previously been demonstrated by our lab that allogeneic MSCs prolong corneal allograft survival however syngeneic MSCs fail to do so. The aim of this study was to investigate if pre-treating syngeneic MSCs with ...
Invasive haemodynamic characteristics and clinical outcomes of patients presenting with symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation
(2016-01-12)
The present thesis is comprised of an introduction followed by eight chapters. The introduction gives an overview of the transcatheter aortic valve implantation (TAVI) procedure and details the patient selection process. ...
A prospective evaluation of involuntary admission from the viewpoint of service users
(2016-09-19)
Introduction:
Involuntary admission is often a traumatic experience for patients and it is associated with
negative attitudes which can persist after the episode of illness has abated.
Aims:
The aims of the study were ...
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)
It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ...
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
(2016-04-22)
The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ...
Genotype-dependent responsivity to inflammatory pain: the role of TRPV1 in the periaqueductal grey
(2016-09-21)
The ability to experience pain is essential for survival, and to prevent potential tissue damage upon exposure to noxious stimuli. The periaqueductal grey - rostral ventromedial medulla – dorsal horn of the spinal cord ...
Trends in the incidence and outcomes of end stage kidney disease from specific causes and the ability of measures of kidney function to predict mortality in community dwelling individuals
(NUI Galway, 2018-03-09)
Summary of Contents
There are two broad themes in this research thesis. The first is an exploration of the ability of measures of kidney function and urinary protein excretion to predict death based on non-parametric ...
Therapeutic applications of endothelial progenitor cells for diabetic ulcer healing
(2016-10-16)
Diabetic ulcer healing is a major problem in health care. Impaired circulation has long been associated with diabetes resulting in an increased risk of foot ulceration and making an increase in blood flow an excellent ...
Characterisation of triple negative breast carcinoma and identification of the value of immunohistochemical markers and stromal tumour infiltrating lymphocytes
(NUI Galway, 2017-10)
Breast cancer is a complex disease that encompasses multiple molecular subtypes that have different clinical behavior. The behavior can be influenced by both the characteristics of the cancer cells as well as the surrounding ...
An investigation of neuroanatomical contributions to cognitive deficits associated with psychotic illness: A 4 year longitudinal follow-up study
(2017-02-20)
Introduction: In general, individuals who experience a first-episode of psychosis (FEP) display deficits on a wide range of neuropsychological tasks compared to psychiatrically healthy individuals (Bora et al., 2014). ...