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Role of LPS/TLR4 and complement signaling in liver regeneration after partial hepatectomy
(NUI Galway, 2018-04-25)
Liver regeneration after partial hepatectomy (PH) is a complex process involving an inflammatory response that is followed by the proliferation of both parenchymal and nonparenchymal liver cells to restore the lost liver ...
An examination of the effects of viral priming on neurotoxin induced synapse dysfunction and degeneration
(NUI Galway, 2018-10-19)
Over 200 years since its first description, Parkinson’s disease (PD) remains the second most common neurodegenerative disorder. Treatments are insufficient and there is still no cure. The continued lack of treatment ...
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)
NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ...
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
(NUI Galway, 2018-12-14)
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ...
Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
(NUI Galway, 2018-12-20)
The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ...